Objective Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate i…
PAIN publishes research on the nature, mechanisms and treatment of pain. The journal provides a forum for the dissemination of research in the basic and…
Defining the extracellular matrix in non-cartilage soft-tissues in osteoarthritis: a systematic review
Nature Reviews Rheumatology – Synovial dendritic cell profiles and localization patterns provide insights about the roles of dendritic cell subsets in the initiation, remission and…
Nature Reviews Rheumatology – In a new study, inhibition of CDK7 disrupted the RNA polymerase II transcription cycle, leading to anti-inflammatory effects and metabolic reprogramming…
Nature Reviews Rheumatology – Here, we highlight three publications in 2024 that have advanced the field of molecular and immunological profiling, for the diagnosis, prognosis…
Bone stress injuries, commonly referred to as stress reactions and stress fractures, represent overuse injuries to bone. These injuries result in physical limitations in activity…
Nature Reviews Rheumatology – Emerging research in intervertebral disc degeneration in 2024 highlights microbial, immune and inflammatory mechanisms that drive chronic low back pain. These…
Topic(s): Basic & Clinical Sciences, Metabolic Bone Disease, Other Rheumatic & Connective Tissue Disorders, Pain Syndromes, Rheumatoid Arthritis Launch Date: Thursday, December 19, 2024, 1:00…
known about the mechanisms underlying progression to multiple (more than 1) COPCs. This study aims to address the gap by investigating the role of common…
l pain nucleus. Rather, it is a complex “signature” of brain activity normally driven by sensory stimuli, but in the event of pathology also from…
