A developmental transition occurs between fetal and adult hematopoietic stem cells. How the 3D genome folding contributes to this transition is poorly understood. Chen et al. show global genome organization is largely conserved, but a large fraction of enhancer-promoter interactions is re-organized and regulate genes contributing to the phenotypic differences.
“When I meet patients who tell me: ‘You saved my life,’ it is an unforgettable moment.” Read about laureates James P. Allison and Tasuku Honjo…
Spatial transcriptomics (ST) combines single-cell RNA-seq gene expression data with spatial coordinates to provide an accurate, 2D picture of gene expression across a tissue sample.…
The androgen receptor (AR) is a master regulator in prostate cancer, but the relevance of its truncated variants remains unclear. Using patient-derived models, we demonstrated…
Abstract. The development of treatment resistance remains universal for patients with metastatic prostate cancer, driven by AR alterations and lineage state transitions. Identifying the evolution…
Abstract. The development of treatment resistance remains universal for patients with metastatic prostate cancer, driven by AR alterations and lineage state transitions. Identifying the evolution…
ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.
Cheers to a year of breakthroughs at Atlasxomics—and an even more innovative 2025 ahead! Together, let’s push the boundaries of discovery. #epigenetics…
Understanding how prostate cancers adapt to AR-targeted interventions is critical for identifying novel drug targets to improve the clinical management of treatment-resistant disease. Our study…
Toni Choueiri: Honored by the King Hussein Cancer Foundation / cancer, Dana-Farber Cancer Institute, DFCI, HRH Princess Ghida Talal, King Hussein Cancer
Toni Choueiri: Honored by the King Hussein Cancer Foundation / cancer, Dana-Farber Cancer Institute, DFCI, HRH Princess Ghida Talal, King Hussein Cancer
