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Mashup Score: 5Online Event - 11 day(s) ago
In vitro-transcribed mRNAs have been proven efficient in various therapeutic applications. However, manufacturing them poses challenges due in part to complexity of the molecules as well as the intricate balancing of reagents in the reaction to balance out potency and integrity. In vitro transcription (IVT) and capping reactions are not one-size-fits all, rather they must be tuned to individual molecules based on their composition, structure, and size to truly optimize mRNA development. Optimizing the
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Mashup Score: 11Online Event - 13 day(s) ago
While humanized animalmodels are relatively new to drug development compared to their non-humanizedcounterparts, they are critical tools in the landscape of biologic drugdevelopment. Their success is due to the ability of humanized models to developersrefine their therapies to boost efficacy and reduce toxicity which is crucialfor advancing them to the clinic. In this GEN webinar, Aaron Rose, PhD, explores how biological therapeutics are reshaping the traditional drug development process and why humanized
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Mashup Score: 23Online Event - 14 day(s) ago
The next generation of predictive cancer biomarkers must move away from the reductionist view of biology and become more representative of the complex and functional biology underpinning clinical responses. Cutting-edge spatial biology technologies, such as multiplex immunofluorescence (mIF), are ushering in a new class of digital biomarkers and algorithms that capture the systems-view of disease biology and can ultimately lead to improved patient outcomes. The challenge with adopting new spatial biology
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Mashup Score: 16Online Event - 16 day(s) ago
Quantitative real-time PCR (qPCR) and digital PCR (dPCR) are powerful molecular biology techniques for quantifying and analyzing DNA or RNA, but they differ in their approach and applications. Traditional qPCR is widely used for detecting and quantifying highly specific DNA or RNA sequences in a range of research and clinical diagnostic applications. However, dPCR technology offers greater precision and sensitivity than qPCR, and is designed to handle tasks requiring precise quantification. In this GEN
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Mashup Score: 4Online Event - 17 day(s) ago
Developing a biosimilar drug requires screening many samples originating from different cell lines to select the most appropriate ones for further process development. Each sample needs to be characterized by their critical q uality attributes, such as glycosylation or charge variants, which can be used to identify potentially harmful modifications in the samples. Common techniques used to determine the charge variants of a sample, such as ion exchange chromatography, are time- and material-consuming and
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Mashup Score: 10Online Event - 18 day(s) ago
About five million people in the United States alone live with traumatic brain injuries (TBIs). These injuries can quadruple the risk of developing Alzheimer’s disease, and other dementias, and increase the likelihood of developing neurodegenerative diseases such as amyotrophic lateral sclerosis. Rodent models of TBI have clarified some aspects of these injuries; however, most treatment approaches have had limited success because some of the details of the underlying mechanisms are still unclear. In this
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Mashup Score: 16Online Event - 19 day(s) ago
Quantitative real-time PCR (qPCR) and digital PCR (dPCR) are powerful molecular biology techniques for quantifying and analyzing DNA or RNA, but they differ in their approach and applications. Traditional qPCR is widely used for detecting and quantifying highly specific DNA or RNA sequences in a range of research and clinical diagnostic applications. However, dPCR technology offers greater precision and sensitivity than qPCR, and is designed to handle tasks requiring precise quantification. In this GEN
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Mashup Score: 16Online Event - 20 day(s) ago
New tools and platforms to accelerate vaccine development and manufacturing are in high demand and short supply. InDevR’s VaxArray Platform is a microarray-based system for multiplexed analysis, with a wide range of applications in vaccine analytics including identity testing, antigen quantification, serum antibody quantification, nucleic acid vaccine construct characterization, and cell-based potency. In this webinar, Dr. Kopcho will demonstrate the flexibility of the VaxArray platform through a variety
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Mashup Score: 7Online Event - 21 day(s) ago
Workflow design and data management are pivotal components of cell and gene therapy research and development. Advances in artificial intelligence, informatics, and automation have made it possible to optimize experimental design, automate laboratory workflows, simplify process configurations, manage data, and accelerate analysis in cell and gene therapy research and development. These technological advancements are speeding up research into new therapies and enhancing the precision and reliability of
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Mashup Score: 10Online Event - 22 day(s) ago
Gene therapy has undergone a renaissance in recent years, with several drugs offering beneficial, even life-saving treatments, now approved by the FDA. One example was reported earlier this year, with the progress made by two separate research teams working on gene therapy programs targeting hearing loss. And the FDA has stated that they expect an increase in the number of authorizations of gene therapy treatments over the next few years. But getting gene therapies into patients is a challenging road. On
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New GEN Live! On 4/24, we will discuss the state of gene therapy today, the promises and pitfalls of delivery vectors, the challenge posed by the immune response, and the safety issues that need to be addressed going forward. REGISTER: https://t.co/cR7OYroiD6 @ElegenBio #CRISPRs https://t.co/zzajirU2Qi
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New webinar! On 5/23, Scott Alderucci will discuss ways of leveraging new technologies and experimental design for an optimized, tailored approach to mRNA therapy development. REGISTER: https://t.co/fdwJ6VHevN @CuriaCDMO #Biologics #DrugManufacturing #mRNA #Bioprocessing https://t.co/FRL7c09tIr