• Mashup Score: 1

    There exists a tremendous opportunity in identifying and determining the appropriate predictive and prognostic biomarker(s) for risk stratification of patients with colorectal cancers (CRCs). Circulating tumor DNA (ctDNA) has emerged as a promising prognostic and possibly predictive biomarker in the personalized management of patients with CRCs. The disease is particularly suited to a liquid…

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    • RT @QxMD: Using Circulating Tumor DNA in Colorectal Cancer: Current and Evolving Practices: https://t.co/2f1XfsHGJL

  • Mashup Score: 7

    Hepatorenal syndrome (HRS) is a serious form of renal dysfunction in patients with cirrhosis and ascites. It is an important component of the acute-on-chronic liver failure (ACLF) syndrome. Significant recent changes in the understanding of the pathophysiology of renal dysfunction in cirrhosis include the role of inflammation in addition to hemodynamic changes. The term acute kidney injury (AKI)…

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    • RT @drkeithsiau: Management of AKI (and HRS) in cirrhosis: a recent update #LiverTwitter #MedEd (Via @QxMD) https://t.co/1UvEVLIyb1 https:…

  • Mashup Score: 6

    Vaccination is crucial for avoiding infection-associated morbidity and mortality among immunocompromised patients. However, immunocompromised patients respond less well to vaccinations compared to healthy people, and little is known about the relative efficacy of various vaccines among different immunocompromised states. A total of 54 systematic reviews (22 COVID-19; 32 non-COVID-19) published…

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    • This important review looks at conditions where vaccines don't work as well (B-cell-depleting agents (e.g., anti-CD20 therapy), hematopoietic stem-cell transplant, solid organ transplant, and liver cirrhosis): groups that need additional boosts & Evusheld https://t.co/mHwZYItyQF

  • Mashup Score: 13

    Liver biochemical tests are some of the most commonly ordered routine tests in the inpatient and outpatient setting, especially with the automatization of testing in this technological era. These tests include aminotransferases, alkaline phosphatase, gamma-glutamyl transferase, bilirubin, albumin, prothrombin time and international normalized ratio (INR). Abnormal liver biochemical tests can be…

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    • RT @drkeithsiau: Abnormal LFTs: a review for clinicians #LiverTwitter #4KMedEd (Via @QxMD) https://t.co/wQtHJZBDR3 https://t.co/SiAyYROzhC

  • Mashup Score: 34

    Hemochromatosis (HC) is a genetically heterogeneous disorder in which uncontrolled intestinal iron absorption may lead to progressive iron overload responsible for disabling and life-threatening complications such as arthritis, diabetes, heart failure, hepatic cirrhosis, and hepatocellular carcinoma. The recent advances in the knowledge of pathophysiology and molecular basis of iron metabolism…

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    • RT @drkeithsiau: New classification of haemochromatosis 🆓 #LiverTwitter #GITwitter (Via @QxMD in @BloodJournal) https://t.co/vN2lUoXu3V ht…

  • Mashup Score: 4

    BACKGROUND: The introduction of multi-agent chemotherapy and radiation therapy has facilitated potential resection with curative intent in selected locally advanced pancreatic cancer (LAPC) patients with excellent outcomes. Nevertheless, there remains a remarkable lack of consensus on the management of LAPC. We sought to describe the outcomes of patients with LAPC and objectively define the…

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    • Operability is still in the eye of the (surgical) beholder but the Johns Hopkins anatomic LAPC score provides an objective system to anticipate the probability of eventual resection after induction therapy @hopkinssurgery @HopkinsJSCOR #pancsm via @QxMD https://t.co/2pJDTcq9qU

  • Mashup Score: 2

    INTRODUCTION: The U.S. Affordable Care Act Medicaid expansion, which allowed states to expand Medicaid coverage to low-income adults beginning in 2014, has reduced the risk factors for child neglect and physical abuse, including parental financial insecurity, substance use, and untreated mental illness. This study examines the associations between Medicaid expansion and the rates of overall,…

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    • Another great reason to #expand #Medicaid (do we really need more reasons to expand?)… now, a decrease in reported incidents of child neglect and physical abuse. https://t.co/GxSjGMFjdC