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Mashup Score: 1
There exists a tremendous opportunity in identifying and determining the appropriate predictive and prognostic biomarker(s) for risk stratification of patients with colorectal cancers (CRCs). Circulating tumor DNA (ctDNA) has emerged as a promising prognostic and possibly predictive biomarker in the personalized management of patients with CRCs. The disease is particularly suited to a liquid…
Source: read.qxmd.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 7
Hepatorenal syndrome (HRS) is a serious form of renal dysfunction in patients with cirrhosis and ascites. It is an important component of the acute-on-chronic liver failure (ACLF) syndrome. Significant recent changes in the understanding of the pathophysiology of renal dysfunction in cirrhosis include the role of inflammation in addition to hemodynamic changes. The term acute kidney injury (AKI)…
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Mashup Score: 6Vaccination for the Prevention of Infection among Immunocompromised Patients: A Concise Review of Recent Systematic Reviews. - 2 year(s) ago
Vaccination is crucial for avoiding infection-associated morbidity and mortality among immunocompromised patients. However, immunocompromised patients respond less well to vaccinations compared to healthy people, and little is known about the relative efficacy of various vaccines among different immunocompromised states. A total of 54 systematic reviews (22 COVID-19; 32 non-COVID-19) published…
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Mashup Score: 5
PURPOSE: The phase III ACHIEVE trial conducted in Japan was one of six prospective studies included in the International Duration Evaluation of Adjuvant Therapy collaboration, which explored whether 3 months of adjuvant fluorouracil, leucovorin, and oxaliplatin (FOLFOX) or capecitabine and oxaliplatin (CAPOX) therapy would be noninferior to 6 months of treatment in patients with curatively…
Source: read.qxmd.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 13Abnormal liver enzymes: A review for clinicians. - 2 year(s) ago
Liver biochemical tests are some of the most commonly ordered routine tests in the inpatient and outpatient setting, especially with the automatization of testing in this technological era. These tests include aminotransferases, alkaline phosphatase, gamma-glutamyl transferase, bilirubin, albumin, prothrombin time and international normalized ratio (INR). Abnormal liver biochemical tests can be…
Source: read.qxmd.comCategories: Latest Headlines, PediatricsTweet
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Mashup Score: 34
Hemochromatosis (HC) is a genetically heterogeneous disorder in which uncontrolled intestinal iron absorption may lead to progressive iron overload responsible for disabling and life-threatening complications such as arthritis, diabetes, heart failure, hepatic cirrhosis, and hepatocellular carcinoma. The recent advances in the knowledge of pathophysiology and molecular basis of iron metabolism…
Source: read.qxmd.comCategories: Hematologists1, Latest HeadlinesTweet
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Mashup Score: 2Clinical, echocardiographic and hemodynamic predictors of right heart failure after LVAD placement. - 3 year(s) ago
Right ventricular failure (RVF) after left ventricular assist device (LVAD) implant is associated with increasing morbidity and mortality. The aim of this study was to identify the best predictors of RVF post LVAD-implant among biochemical, haemodynamic and echocardiographic parameters. From 2009 to 2019, 38 patients who underwent LVAD implantation at our centre were prospectively enrolled….
Source: read.qxmd.comCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 4
BACKGROUND: The introduction of multi-agent chemotherapy and radiation therapy has facilitated potential resection with curative intent in selected locally advanced pancreatic cancer (LAPC) patients with excellent outcomes. Nevertheless, there remains a remarkable lack of consensus on the management of LAPC. We sought to describe the outcomes of patients with LAPC and objectively define the…
Source: read.qxmd.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 2Impact of Medicaid Expansion on Reported Incidents of Child Neglect and Physical Abuse. - 3 year(s) ago
INTRODUCTION: The U.S. Affordable Care Act Medicaid expansion, which allowed states to expand Medicaid coverage to low-income adults beginning in 2014, has reduced the risk factors for child neglect and physical abuse, including parental financial insecurity, substance use, and untreated mental illness. This study examines the associations between Medicaid expansion and the rates of overall,…
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Mashup Score: 1Young people's romantic relationships and sexual activity before and during the COVID-19 pandemic. - 3 year(s) ago
BACKGROUND: Social distancing measures to reduce the spread of COVID-19 may profoundly impact young people’s relationships. This study compared adolescent and young adults’ romantic relationships and sexual activity before and after social distancing policies were enacted. METHODS: In June 2020, 351 youth participating in an ongoing intervention study in Fresno County, California completed an…
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RT @QxMD: Using Circulating Tumor DNA in Colorectal Cancer: Current and Evolving Practices: https://t.co/2f1XfsHGJL