Pemphigus vulgaris affects approximately 0.1 and 0.5 per 100,000 people per year (Langan et al., 2008); it has a striking morbidity and mortality reported as high as 5% in recent cohort studies (Uzun et al., 2006). There is no sex predominance, and the mean age of onset is often in the sixth decade of life unless associated with hematological or solid-organ malignancy (paraneoplastic autoimmune…

Itch is a common symptom of skin conditions such as psoriasis (Elewski et al. 2019). The processing of itch-related information can be influenced by implicit processes such as biased avoidance tendencies (Silverberg et al. 2018; Verhoeven et al. 2006) and attentional biases (Evers et al. 2019; van Laarhoven et al. 2020) which can amplify the sensation of itch. These processes can especially…

Atopic dermatitis (AD) and psoriasis (Pso) are common systemic inflammatory skin diseases in which dendritic cells (DCs) and macrophages (MØs) play central roles. Clarifying the cell subsets which are involved in the pathogenesis of AD and Pso is a prerequisite to developing effective treatments. Our research focuses on macrophage galactose-type C-type lectin (MGL/CLEC10A/CD301), hereafter called…

Unbiased informatics approaches have the potential to generate insights into uncharacterized signaling pathways in human disease. Here, we generated longitudinal transcriptomic profiles of plaque psoriasis lesions from patients enrolled in a clinical trial of the anti-IL17A antibody ixekizumab (IXE). This dataset was then computed against a curated matrix of over 700 million data points derived…

Dupilumab, an IgG4 monoclonal antibody targeting the interleukin-4 receptor alpha (IL-4Rα), substantially improves disease severity in patients with atopic dermatitis (AD) (Worm et al., 2020).

Atopic dermatitis (AD) is a common inflammatory skin disorder characterized by a heterogeneous and fluctuating disease course. To obtain a detailed molecular understanding of both the temporal and spatial variation in AD, we conducted a longitudinal case-control study, in which we followed a population, the GENAD (Gentofte AD) cohort, of mild-to-moderate patients with AD and matched healthy…

Ulcerated cutaneous melanoma carries a poor prognosis, and the underlying biology driving its aggressive behavior is largely unexplored. MicroRNAs (miRs) are small, noncoding RNAs that inhibit the expression of specific genes and exhibit dysregulated expression patterns in cancer. We hypothesized that a unique miR profile exists in ulcerated relative to nonulcerated melanoma and that miR…

The skin acts as an endocrine organ capable of hormone production and response. Moreover, many skin conditions clinically improve with antiandrogen therapies. Despite their importance, we have an incomplete understanding of the composition of hormones produced by the skin. In this study, we have characterized the hormonal landscape of the skin across anatomical sites and between the sexes through…