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Mashup Score: 4
Background Determination of programmed death-ligand 1 (PD-L1) protein expression level in tumor cells and tumor-associated immune cells is critical for identifying patients eligible for immunotherapy. PD-L1 manual scoring algorithms can generally be divided into two categories: cell counting and visual estimation. Cell counting can be time-consuming and is not in sync with pathology practice, which classically uses a Gestalt approach based on pattern recognition and visual estimation. In this study, we introduce the Tumor Area Positivity (TAP) score, which is a novel, straightforward method for scoring tumor cells and immune cells together using visual estimation. Methods To demonstrate the reproducibility of TAP scoring among pathologists, between- and within-reader precision studies were performed both within (internal) and outside of (external) our organization. We also compared the TAP score to the Combined Positive Score (CPS), which is based on cell counting, for concordance and
Categories: General Medicine News, Hem/OncsTweet
Table 1 in the below report on Tumor Area Positivity (TAP) score for PD-L1: Summary of on-market FDA-approved PD-L1 IHC scoring algorithms and associated testing assays. #GI24 https://t.co/gPgxMUQDg2 @DiagnosPath https://t.co/wuSbwIaKiK https://t.co/t9trhF7CXx