Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) was established by the NIH/NIDDK in 2012 to study lower urinary tract disorders. There are 2 LURN studies. LURN I (the first phase of the LURN Study) studied lower urinary tract symptoms (LUTS) in men and women. LURN II (the second phase of the LURN Study) studied urinary urgency, with or without urgency urinary incontinence (UUI), in men and women (ie, with overactive bladder). In this article, we highlighted some of the findings from the LURN studies. This presentation was given at the 2025 Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction meeting celebrating the 75th anniversary of the NIDDK.

When patients, families, and advocacy groups engage in promoting research, great strides have been made in understanding many disorders and pushing forward the development of new therapies. Bringing together all the stakeholders (patients, families, physicians, researchers, funding sources, Food and Drug Administration and industry) results in a strong collaborative effort to define patient needs, outcome measures, and implement high-level evidence into clinical practice. Engaging patients and caregivers in clinical trial ideation and design can help ensure these trials are feasible, impactful, and will optimize recruitment and retention. Engaging frontline clinicians in implementation research will help to understand gaps in care and utilization of care guidelines derived from these high-impact clinical trials. In kidney stone disease, guidelines exist for evaluation of patients with idiopathic stone disease and cystinuria. Variations in guideline-adherent care may suggest gaps in kno