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Mashup Score: 6Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares - 11 month(s) ago
Objective Whereas genetic susceptibility for systemic lupus erythematosus (SLE) has been well explored, the triggers for clinical disease flares remain elusive. To investigate relationships between microbiota community resilience and disease activity, we performed the first longitudinal analyses of lupus gut-microbiota communities. Methods In an observational study, taxononomic analyses,…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet
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Mashup Score: 1Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis - 11 month(s) ago
Objectives The activator protein-1 (AP-1) transcription factor component c-Fos regulates chondrocyte proliferation and differentiation, but its involvement in osteoarthritis (OA) has not been functionally assessed. Methods c-Fos expression was evaluated by immunohistochemistry on articular cartilage sections from patients with OA and mice subjected to the destabilisation of the medial meniscus…
Source: Annals of the Rheumatic DiseasesCategories: Healthcare Professionals, Latest HeadlinesTweet-
c-Fos regulates chondrocyte proliferation and differentiation, and cFOS-positive chondrocytes were increased in human and murine OA cartilage. New research (humans an mice) suggests it plays a role in protecting cartilage and could be a therpeutic target https://t.co/B0tmo0AbQe https://t.co/KPrOm3Spfa
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Mashup Score: 6
In recent years, treat-to-target strategy and early intervention strategies with immunosuppressive agents have attempted to improve the prognosis and outcome in patients with autoimmune inflammatory rheumatic diseases. However, infectious complications due to side effects of medication remain a major concern in routine practice. In this regard, vaccine immunity and vaccination programmes are of…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet-
Do you take care of #SLE patients on #biologics? 🦋 All you wanted to know about #vaccinations💉but never dared to ask for is here in this review! 👇 🔴 pneumococcus ⚪ influenza ⚫ SARS-CoV-2 🔵 varicella zoster ⭕ tetanus 🔘 other non-live 💉 👉 https://t.co/5B2PjNmTTO https://t.co/8Pe9yYj95Y
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Mashup Score: 1
Objective Obesity is a risk factor for knee osteoarthritis (KOA) development and progression. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are indicated for type 2 diabetes mellitus (T2DM) and obesity. However, whether KOA patients can benefit from GLP-1RA therapies has not been sufficiently investigated, especially in the long term. Methods The Shanghai Osteoarthritis Cohort study is a…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet-
What is the benefit of GLP1 receptor agonists on knee #osteoarthritis? ▶️ GLP1-receptor agonist reduced decreased knee surgery need in patients with #osteoarthritis & diabetes 🔗 https://t.co/FtXZN0W6PO https://t.co/Wykh1zoBm6
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Mashup Score: 0EULAR points to consider for the definition of clinical and imaging features suspicious for progression from psoriasis to psoriatic arthritis - 11 month(s) ago
Background The transition from psoriasis (PsO) to psoriatic arthritis (PsA) and the early diagnosis of PsA is of considerable scientific and clinical interest for the prevention and interception of PsA. Objective To formulate EULAR points to consider (PtC) for the development of data-driven guidance and consensus for clinical trials and clinical practice in the field of prevention or…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet-
Have you checked the latest recommendations? @eular_org points to consider for the definition of clinical and imaging features suspicious for progression from PsO to PsA ▶️ 3 stages relevant to PsA prevention ▶️ 5 OP and 10 points to consider 🔗 https://t.co/Kr9akTjNC6 https://t.co/cHsg0ZTlb6
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Mashup Score: 0Incidence, prevalence and mortality of IgG4-related disease in the USA: a claims-based analysis of commercially insured adults - 11 month(s) ago
Background IgG4-related disease (IgG4-RD) is an immune-mediated condition that can affect nearly any organ or anatomic site. We sought to describe the epidemiology of IgG4-RD in the USA. Methods We used Optum’s deidentified Clinformatics Data Mart Database from 1 January 2009 to 31 December 2021 to identify IgG4-RD cases using a validated algorithm. We estimated the incidence rate and prevalence…
Source: Annals of the Rheumatic DiseasesCategories: Healthcare Professionals, Latest HeadlinesTweet-
Using Optum claims data from 2009 to 2021, they identified 524 IgG4-RD pts (mean age 56 yrs), incidence increased over time 0.78 to 1.39/100K Pt Yrs 2015 and 2019. Prevalence (1/19) was 5.3/100K Pt-Yrs, w/ mortality rate 3.42/100 Pt-Yrs (HR 2.51) https://t.co/22eIjtC7kp https://t.co/8RlEtZiX9j
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Mashup Score: 8
Introduction Current scientific evidence guiding the decision whether men with an active desire to become a father should be treated with methotrexate (MTX) remains controversial. We aimed to prospectively evaluate the testicular toxicity profile of MTX focusing on several markers of male fertility, including semen parameters and sperm DNA fragmentation index (sDFI). As a secondary outcome, we…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet-
Is #methrotexate related to men fertility? Check out the results of the iFAME-MTX study: ▶️ MTX pre- and post-exposure does not affect semen parameters ▶️ no differences vs controls ▶️ MTX only marginally accumulated in spermatozoa 🔗 https://t.co/K92xdq7aP6 @DrReumatologo https://t.co/faE6kxMx2n
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Mashup Score: 0ASAS consensus definition of early axial spondyloarthritis - 11 month(s) ago
Objectives To develop a consensual definition for the term ‘early axial spondyloarthritis—axSpA’—and ‘early peripheral spondyloarthritis—pSpA’. Methods The ASAS (Assessment of SpondyloArthritis international Society-Spondyloarthritis EARly definition) steering committee convened an international working group (WG). Five consecutive steps were followed: (1) systematic literature review (SLR); (2)…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet-
Check out the latest recommendations: ASAS consensus definition of early axial spondyloarthritis ▶️ early axSpA: sumptoms duration <2 years ▶️ axial symptoms: cervical, thoracic, back, buttock pain or morning stiffness 🔗 https://t.co/vcab2CXJso @annamolto, @sofiaramiro82 https://t.co/mAoX4wRIAG
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Mashup Score: 0Tripterygium wilfordii derivative celastrol, a YAP inhibitor, has antifibrotic effects in systemic sclerosis - 11 month(s) ago
Objectives Systemic sclerosis (SSc) is characterised by extensive tissue fibrosis maintained by mechanotranductive/proadhesive signalling. Drugs targeting this pathway are therefore of likely therapeutic benefit. The mechanosensitive transcriptional co-activator, yes activated protein-1 (YAP1), is activated in SSc fibroblasts. The terpenoid celastrol is a YAP1 inhibitor; however, if celastrol can…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet-
What is new on the treatment of #systemic #sclerosis? ▶️ celastrol impairs fibrotic phenotype of fibroblasts ▶️ celastrol counteracts bleomycin-induced gene expression programmes ▶️ celastrol antagonise the mechanosensitive YAP pathway 🔗 https://t.co/y499g49s6W
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Mashup Score: 0Country-level socioeconomic status relates geographical latitude to the onset of RA: a worldwide cross-sectional analysis in the METEOR registry - 11 month(s) ago
Objective Age at rheumatoid arthritis (RA) onset varies by geographical latitude. We have investigated to what extent differences in patient-specific factors and country-level socioeconomic indicators explain this variability. Methods Patients with RA from the worldwide METEOR registry were included. Bayesian multilevel structural equation models were used to study the relationship between the…
Source: Annals of the Rheumatic DiseasesCategories: Latest Headlines, RheumatologyTweet-
Interested in how geographical factors could impact 3rheumatoid #arthritis characteristics? Data from the METEOR registry demonstrate: ▶️ a latitude gradient in age at onset in RA ▶️ socioeconomic rather than biological factors are responsible 🔗 https://t.co/YBFLdjf6ra https://t.co/E3hqkKxt35
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⚠️ New kid on the block among triggers of #flares in #lupus #nephritis 🦋 📈 Longitudinal gut #microbiota analysis 🔬 💥 #Ruminococcus gnavus bloomed during flares 🆕 Novel immunogenic #lipoglycan recognised by IgG2 🆙 specific #IgG2 ⬆️ ⬆️ in flares https://t.co/MpdETeo7iY https://t.co/dLmS0L4k8j