Nature Reviews Rheumatology
Nature Reviews Rheumatology is a peer-reviewed journal for rheumatologists and affiliated healthcare professionals. The journal delivers timely …
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Clonal dominance: mutations in VEXAS syndrome take advantage of inflammation
Nature Reviews Rheumatology – VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is caused by somatic mutations in UBA1 arising in hematopoietic stem cells, resulting…
Advances in the treatment of ANCA-associated vasculitis
Nature Reviews Rheumatology – This Review discusses the advances and challenges of managing antineutrophil cytoplasmic antibody-associated vasculitis. The authors discuss current treatment options,…
Efficacy and safety of subcutaneous abatacept + standard treatment for active idiopathic inflammatory myopathy: phase III randomised controlled trial
Objective To evaluate the efficacy and safety of subcutaneous (SC) abatacept and standard of care (SOC) for the treatment of idiopathic inflammatory myopathy (IIM) over…
Insights into Lyme arthritis
Nature Reviews Rheumatology – Two complimentary studies provide a deeper understanding of Lyme disease and the associated chronic complications, such as Lyme arthritis.
How JAK inhibitors tip the prothrombotic balance in rheumatoid arthritis
Nature Reviews Rheumatology – The increased incidence of deep vein thromboses and pulmonary emboli has long been noted in rheumatoid arthritis and has been ascribed…
Fibroblasts in immune responses, inflammatory diseases and therapeutic implications
Nature Reviews Rheumatology – This Review provides a comprehensive overview of fibroblast biology in rheumatoid arthritis and other chronic inflammatory diseases. The authors discuss insights…
The pathogenesis, clinical presentations and treatment of monogenic systemic vasculitis
Nature Reviews Rheumatology – This Review discusses the clinical features, pathogenesis, diagnosis and management of monogenic forms of vasculitis. The authors emphasize that increased awareness…
Region-specific, data-driven guidelines are needed for rheumatic diseases in LMICs
Nature Reviews Rheumatology – Separate guidelines are needed for the management and diagnosis of rheumatic diseases in low- and middle-income countries, especially with the advent…
Understanding rheumatic disease through continuous cell state analysis
Nature Reviews Rheumatology – This Review explores the ongoing debate regarding the definition of cell identity, with a focus on the immune and stromal cell…
Arterial and venous thrombosis in systemic and monogenic vasculitis
Nature Reviews Rheumatology – Systemic vasculitis, including monogenic forms, is associated with an increased risk of arterial and venous thromboembolic events (AVTEs). This Review highlights…