The COVID-19 pandemic has revealed the pronounced vulnerability of the elderly and chronically-ill to SARS-CoV-2-induced morbidity and mortality. Cellular senescence contributes to inflammation, multiple chronic diseases, and age-related dysfunction, but effects on responses to viral infection are unclear. Here, we demonstrate that senescent cells (SnC) become hyper-inflammatory in response to…
Division of labor among resident tissue macrophages is vital for proper tissue function during homeostasis.
The giant planets of the Solar System formed on initially compact orbits, which transitioned to the current wider configuration by means of an orbital instability.…
Oil and water can only be mixed by dispersing droplets of one fluid in the other. When two droplets approach one another, the thin film…
Nutrition and emission trade-offs of major Japanese dishes were analyzed through optimization modeling.
To understand vulnerable glaciers, climate scientists extract ice from continent’s remote and stormy coast
The pursuit of artificial general intelligence (AGI) continuously demands higher computing performance. Despite the superior processing speed and efficiency of integrated photonic circuits, their capacity…
On 28 April 2006, Science published the Report “Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1a” by C.…
A novelist’s venture into nonfiction is filled with deep insights about life on Earth but may leave some wanting more
Jupiter’s moon Io hosts extensive volcanism, driven by tidal heating. The isotopic composition of Io’s inventory of volatile chemical elements, including sulfur and chlorine, reflects…
Therapeutic oligonucleotides are a powerful drug modality with the potential to treat many diseases. The rapidly growing number of therapies that have been approved and…
