Sedation and Ventilator Weaning Bundle and Time to… : Pediatric Critical Care Medicine
Design: Post hoc subgroup analysis of a cluster-randomized trial, 2018 to 2019 (ISRCTN16998143). Patients: Surviving patients with bronchiolitis under 1 year of age in the SANDWICH trial (n = 784). Interventions: Nil. Measurements and Main Results: Time to successful extubation, and rates of unplanned and failed extubation were compared in patients exposed and not exposed to the intervention. To explore a site-level effect, we tested the correlation between the rate of unplanned and failed extubation at each trial site with the median time to successful extubation at that site. Of 784 patients (48%), 376 were exposed to the intervention. Median (interquartile range [IQR]) time to successful extubation was 69.6 (IQR 50.4–110.4) hours in patients exposed to the intervention and 86.4 (IQR 60–124.8) hours in non-exposed. Exposure to the SANDWICH intervention was associated with a 13% (95% CI, 1%–26%) reduction in time to extubation following adjustment for confounders. Thirty (3.8%) patien
