Reduced Cytokine Release Syndrome and Improved Outcomes with Earlier Immunosuppressive Therapy in Haploidentical Stem Cell Transplantation
Classically, the optimal donors for patients requiring hematopoietic stem cell transplantation (HSCT) have been HLA-matched relatives or unrelated donors in the National Marrow Donor Program registry. For many patients, such as those of an ethnic minority, an HLA-matched donor might not be available [1]. Haploidentical HSCT (haplo-HSCT) has provided additional donor options for most patients who lack an HLA-matched donor. Potential donors for haplo-HSCT include parents, siblings, and children.