Proposed framework for unifying disease definitions in guideline development
A disease definition refers to the precise and clear characterisation or description of a particular medical condition or illness. A disease definition aims to provide a comprehensive understanding of the nature, symptoms and characteristics of the disease. A clear definition is critical for generating research, synthesis of evidence, decision-making and implementation of recommendations.1 It is also important for payors and policymakers. However, different medical societies, governmental agencies, researchers and patient advocacy groups may use different definitions for the same entity.2–4 In addition to the variation of the definition itself and its components, the terminology used to convey the definition may vary (ie, the specific vocabulary, nomenclature and language used to describe the definition). In the context of clinical practice guidelines, the lack of consistent definitions for certain diseases can impede the development of a recommendation based on a clear target populati
