In this population-based study, maternal history of early-onset colorectal cancer was associated with risk of both adverse pregnancy (pre-eclampsia, C-section) and neonatal outcomes (preterm birth).
Your participation in the CariGenetics X Daily Male Caribbean Prostate Cancer Whole Genome Pilot Study is a significant contribution to our mission of understanding the…
Alruwaili et al. demonstrate that p53-mutant cancer cells accumulate DNA breaks due to post-replicative removal of thymidine analogs following DNA replication. Inhibition of PARP enhances DNA…
Abstract. Tyrosine kinase inhibitors (TKIs) that block the vascular endothelial growth factor receptors (VEGFRs) disrupt tumor angiogenesis but also have many unexpected side-effects that impact…
Cell cycle events are coordinated by cyclin-dependent kinases (CDKs) to ensure robust cell division. CDK4/6 and CDK2 regulate the growth 1 (G1) to synthesis (S)…
For people with no family history of colon cancer or other risk factors Swedish researchers found that screening every 15 years was still protective.
Communications Medicine – Nunez et al. investigate the use of natural language processing to predict which patients with cancer will see a psychiatrist or counselling…
npj Precision Oncology – Genome-matched treatments and patient outcomes in the Maine Cancer Genomics Initiative (MCGI)
Systemically administered mRNA aggregates (RNA-LPA) transfect lymphoreticular organs, inducing a massive cytokine/chemokine response that rapidly reprograms the tumor microenvironment while mobilizing dendritic cells/lymphocytes to elicit…
npj Precision Oncology – Comparative molecular profiling of pancreatic ductal adenocarcinoma of the head versus body and tail
Nature Biomedical Engineering – The removal of terminal sialic acid residues on glycans at the T-cell–tumour-cell interface via a sialidase fused to a bispecific T-cell…
