Pre-race aspirin to enhance primary prevention of marathon-related cardiac arrests: confronting Pheidippides’ legacy

Although increasing levels of physical exercise confer incrementally greater lifetime cardioprotective benefits (marathon training)1, episodes of vigorous physical exertion (the race) transiently increase the risk for acute cardiac events including sudden death 2. Undoubtedly the ultimate overuse sports injury, sudden cardiac death during sport occurs in both elite and recreational athletes3-7….

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