Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus

The largest monkeypox virus (MPXV) outbreak described so far in non-endemic countries was identified in May 20221-6. Here, shotgun metagenomics allowed the rapid reconstruction and phylogenomic characterization of the first MPXV outbreak genome sequences, showing that this MPXV belongs to clade 3 and that the outbreak most likely has a single origin. Although 2022 MPXV (lineage B.1) clustered…

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Source: www.nature.com
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The strain associated with the current monkeypox outbreak is a well-defined divergent branch from the monkeypox viruses of a 2018–19 outbreak in an endemic country that probably represents recent evolutionary changes, according to a @NatureMedicine paper. https://t.co/HKvspHwNbR https://t.co/5HzrFB1Gpn

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