Novel Role of the GSDMB/IFNG Axis in Childhood Asthma
The 17q12–21 region harboring the candidate asthma genes ORMDL3 and GSDMB is the most important and consistently replicated asthma susceptibility locus. The region is strongly associated with early-onset asthma and susceptibility to rhinovirus-induced wheezing but not respiratory syncytial virus wheezing or allergic sensitization (1, 2). Decoding the intervening biology that links 17q variants with asthma pathogenesis has been challenging, because the region comprises 10 candidate genes in the presence