Night science – Genome Biology
If we are woken up in the middle of the night and asked “How does science work?!?”, we rattle off a coherent answer: you have a hypothesis, you use it to make predictions, you test those by comparing them to data, and you throw out or modify the hypothesis if predictions and data di sagree. That’s what our teachers taught us. And it’s not wrong. But this description hides the workings of the most exciting part of science, ignoring the most creative and arguably most significant part of our work. By