Newly Discovered Corneodesmosin Defects in Generalized Pustular Psoriasis
Psoriasis is a heterogeneous chronic inflammatory skin disease, the most common form being psoriasis vulgaris. The less frequent GPP variant (OMIM number 614204) is a life-threatening disease clinically characterized by repeated rashes of painful, giant, and generalized pustules on the skin. These pustules, found in a subcorneal position in the epidermis and called spongiform pustules of Kogoj, are associated with generalized erythema and altered desquamation, e xtreme fatigue, high-grade fever, It is