Nature – Outside influence
The cover shows circular extrachromosomal DNA (ecDNA) sitting next to a chromosome. ecDNA has a significant effect on the outcome of cancer treatment —…
The cover shows circular extrachromosomal DNA (ecDNA) sitting next to a chromosome. ecDNA has a significant effect on the outcome of cancer treatment —…
The importance of surrogate endpoints, magnitude of clinical benefit of cancer drugs, and their prices have often been debated in the oncology world. No study,…
The authors show that gut microbiota imbalances provoke systemic inflammation, leading to immunosuppression in tumors at distant sites, such as the lungs. This accelerates lung…
Nature – Whole-genome sequencing of matched serial tumours from patients identifies two key mutagenic factors (APOBEC3 and chemotherapy) and extrachromosomal DNA-forming structural variants that…
Associations of Internal Medicine Residency Ratings and Certification Examination Scores With Patient Outcomes
Nature Reviews Rheumatology – This Review provides an overview of the pathogenesis, classification and diagnosis of and treatment strategies for adult and paediatric rheumatology patients…
In this issue of Blood, Al-Sawaf and colleagues report on the 6-year results of the CLL14 study, a multicenter open label phase 3 trial for…
The importance of surrogate endpoints, magnitude of clinical benefit of cancer drugs, and their prices have often been debated in the oncology world. No study,…
The US spends more than $100 billion annually on low-value care, or medical tests and treatments that pose unnecessary risks and incur excess costs without…
Trump não venceu por desinformação. Não venceu por alguma artimanha russa. Não houve qualquer conspiração. Os eleitores que votaram nele sabiam exatamente no…
Pediatric Research – Brain volumes and cortical thickness and associations with cognition in children born extremely preterm