Myocardial DNA Damage Is Responsible for the Relationship Between Genotype and Reverse Remodeling in Patients With Dilated Cardiomyopathy | Circulation: Heart Failure
DNA damage response plays a critical role in heart failure, including dilated cardiomyopathy (DCM), and assessment of myocardial DNA damage can predict treatment response and prognosis in patients with DCM. 1 Meanwhile, genotype is also an established predictor of DCM treatment response and prognosis, with nonsarcomere gene variants (LMNA, etc.) predicting poorer prognosis compared with sarcomere gene variants (TTN truncating variants, etc.). 2 However, the relationship between genotype and myocardial
