MAPK-Activating Gene Fusions in Congenital Nevi
Author links open overlay panel Jessica L. Flesher 1, David E. Fisher 1 In individual case studies and small cohorts of patients with CMN, fusion genes have been detected that may drive the formation of the lesion (Martins da Silva et al., 2019; Mir et al., 2019). Starting with a larger cohort, Barberan Martin et al. (2023) have identified 11 unique gene fusion combination pairs present in patients with CMN without BRAF or NRAS variants, 10 of which had not yet been described in CMN. Although there is a