Low Versus High Blood Pressure Targets in Critically Ill… : Critical Care Medicine
ts on mortality. Data Sources: We searched PubMed, Cochrane, and Scholar from inception to February 10, 2024. Study Selection: Randomized trials comparing lower versus higher blood pressure targets in the management of critically ill and perioperative settings. Data Extraction: The primary outcome was all-cause mortality at the longest follow-up available. This review was registered in the Prospective International Register of Systematic Reviews, CRD42023452928. Data Synthesis: Of 2940 studies identified by the search string, 28 (12 in critically ill and 16 in perioperative settings) were included totaling 15,672 patients. Patients in the low blood pressure target group had lower mortality (23 studies included: 1019/7679 [13.3%] vs. 1103/7649 [14.4%]; relative risk 0.93; 95% CI, 0.87–0.99; p = 0.03; I2 = 0%). This corresponded to a 97.4% probability of any increase in mortality with a Bayesian approach. These findings were mainly driven by studies performed in the ICU setting and with