How Efforts to Understand Somatic Mosaicism Will Impact Dermatology
Author links open overlay panel Ryland D. Mortlock 1 2 3, Keith A. Choate 1 2 4 The skin harbors unique SNV signatures compared with other tissues. A higher proportion of somatic SNVs in skin are related to UV light exposure, and skin has a higher overall SNV burden than any other tissue. Damaging SNVs in genes related to skin cancer can be found in normal sun-exposed skin (Martincorena et al, 2015), and their proportion increases with age. In addition, the number of somatic SNVs and the specific signature