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Utilizing a series of cases, an expert panel of nurses will illuminate the journey of patients from paroxysmal nocturnal hemoglobinuria (PNH) to malignant transformation into myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML). In this discourse, our experts will delve into nursing’s best practices for incorporating the patient’s perspective into shared decision making (SDM), effective healthcare provider-patient communication tactics, and pragmatic management approaches including considerations