GZMhi Cytotoxic T Cells: A Key Discovery in Fibrotic Hypersensitivity Pneumonitis
Recent studies have shown that immune dysregulation is relevant to disease progression in interstitial lung diseases (ILDs) (1). Increased monocyte counts and high expression of monocyte-expressed genes have been associated with idiopathic pulmonary fibrosis (IPF) pathogenesis and poor outcomes (2 – 5). Most recently, a single-cell atlas of circulating immune cells in IPF demonstrated an increase in monocytes and regulatory T cells in patients with progressive IPF (6). Contrary to IPF, the role of
