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Key Points. CNB accurately diagnoses lymphoma in most instances but increases the risk of erroneous or nondefinitive conclusions.Systematic expert review highly

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    A review of 32 285 lymph node biopsy cases registered in the French Lymphopath network showed that core needle biopsy provided diagnosis in provided a definitive diagnosis in 92.3% and seemed to be a reliable method of investigation for most patients with suspected lymphoma. Surgical excision provided a definitive diagnosis in 98.1% of cases. Hodgkin lymphoma and T-Cell lymphomas seemed to benefit from the full excision biopsy.