Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity
Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity
Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity
Cancer-associated fibroblasts (CAFs) are recruited and rewired by cancer cells to become protumorigenic. The molecular mechanisms underlying this crosstalk in esophageal cancer are completely unknown.…
Neutrophil extracellular traps (NETs) limit infection by trapping microorganisms and have recently been shown to induce tumor metastasis. In this issue of Cancer Cell, Mousset…
Campbell et al. aggregate genomics and transcriptomics data across melanoma datasets, harmonizing molecular and clinical annotation across samples. Immune cell gene expression patterns and tumor mutational…
de Visser and Joyce review the complex interplay between the tumor and its microenvironment throughout cancer evolution and discuss the tumor cell-intrinsic, cell-extrinsic, and systemic…
The multi-step process of carcinogenesis implies the existence of pre-malignant yet altered states that involve both the potentially carcinogenic cell as well as its surrounding microenvironment.…
Ehmsen et al. evaluate the neutralizing capacity to current SARS-CoV-2 variants in patients with cancer before and after receiving the BNT162b2 bivalent mRNA vaccine booster.…
Circulating tumor cells (CTCs) are regarded as “seeds” of tumor metastasis. By dissecting the interaction between CTCs and immunocytes at single-cell scale, Liu et al. propose…
Song and Chow demonstrate that while tumor-intrinsic mutations in the IFN-γ signaling pathway confer immune resistance across in vitro co-culture systems, such alterations associate with enhanced…
Efforts to apply adoptive cell transfer (ACT) immunotherapy to patients with common epithelial cancers have been stimulated by the demonstration that the majority of these…