Evidence suggests complex roles for oestrogen in females and androgens in males in influencing the risk of dementia or cognitive decline
Commentary on: Han SL, Liu DC, Tan CC, et al . Male- and female-specific reproductive risk factors across the lifespan for dementia or cognitive decline: a systematic review and meta-analysis. BMC Med . 2023 Nov 23;21(1):457. ### Implications for practice and research Dementia and cognitive decline appear more commonly in women than men; these sex differences also vary with age, suggesting that the timing of various hormonal transition phases (eg, menarche and menopause) may influence dementia risk.1 The complexity of these relationships is further complicated by uncertainty about the possible impact of hormone replacement therapy (HRT) and androgen deprivation therapy (ADT) on cognitive outcomes.1 However, prior research findings have demonstrated conflicting results regarding the influence of various …
