Cryo-EM structures and functional analyses of the SARS-CoV-2 B.1.1.7 variant spike protein reveal that the A570D mutation creates a molecular switch to regulate up-down conformations of the ACE2 receptor-binding domain through a pedal-bin-like mechanism.
The immunological basis for allergy-associated aversion to food.
Dinosaurs and mammals have coexisted for the last ~ 230 million years. Both groups arose during the Late Triassic and diversified throughout the Mesozoic and into the…
The chronology and mode of parallel evolution remain unclear. Here, the authors compare mid-Holocene and contemporary bottlenose dolphin adaptations between pelagic and coastal ecosystems with…
A new methodology to study participation genetics via analyzing shared and unshared genotypes is applied to the UK Biobank, suggesting that participating in genetic studies…
The structural search program makes finding proteins with similar 3D shapes easy.
Groundwater springs formed during the retreat of a melting glacier are likely hotspots of methane emissions in the high Arctic according to measurements of methane…
Ideas from computer vision have transformed the way image analysis is performed, with ripple effects across microscopy and biological discovery.
Human activities greatly impact surface water quality, while being reliant upon it for water supply. Surface water quality is expected to change in the future…
Emissions impacts of equitable energy demand reduction approaches are not well understood. A new study finds that capping energy use among top-quintile consumers in Europe…
Specialists offer seven tips for effectively sharing your data.
