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Mashup Score: 0Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction - Critical Care - 1 year(s) ago
Background and Aims The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activated neutrophils during infection and inflammation. We investigated the efficacy of S100A8/A9 blockade as a potential new treatment in SIMD. Methods The relationship between plasma S100A8/A9 and cardiac dysfunction was assessed in a cohort of 62 patients with severe sepsis admitted to the intensive care unit of Linköping University Hospital, Sweden. We used S100A8/A9 blockade with the small-molecule inhibitor ABR-238901 and S100A9−/− mice for therapeutic and mechanistic studies on endotoxemia-induced cardiac dysfunction in mice. Results In sepsis patients, elevated plasma S100A8/A9 was associated with left-ventricular (LV) systolic dysfunction and increased SOFA score. In wild-type mice, 5 mg/kg of bacterial lipopolysaccharide (LPS) induced rapid plasma S100A8/A9
Source: ccforum.biomedcentral.comCategories: Critical Care, Latest HeadlinesTweet
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Mashup Score: 1Paper of the Day - 1 year(s) ago
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2023
Source: criticalcarereviews.comCategories: Critical Care, Latest HeadlinesTweet-
Today's paper of the day is on awake tracheal intubation https://t.co/JKgcYjlUQ5 Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2023 https://t.co/7Qe0BWHNo6
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Mashup Score: 4Journal Watch - 1 year(s) ago
The best critical care literature, updated daily
Source: criticalcarereviews.comCategories: Critical Care, Latest HeadlinesTweet-
Blood-Based Biomarkers in Intracerebral Hemorrhage CCR Journal Watch https://t.co/Sp06oA6IDG Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at https://t.co/nitMzacLrj https://t.co/zTub8CsFpD
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Mashup Score: 23Thousands at risk of dying in Gaza hospitals, cut off by Israel from fuel, water and supplies - 1 year(s) ago
Medics in Gaza warned Sunday that thousands could die as hospitals packed with wounded people ran desperately low on fuel and basic supplies. Palestinians in the besieged coastal enclave struggled to find food, water and safety ahead of an expected Israeli ground offensive in the war sparked by Hamas’ deadly attack.
Source: www.pbs.orgCategories: Critical Care, Latest HeadlinesTweet-
Water is running out. Food is running out. Healthcare in ruins. Remaining hospitals will run out of fuel for generators - and then what will happen to all of these patients on ventilators? This isn't complicated. Ceasefire now. End the siege now. https://t.co/HlEK6Zuocj. https://t.co/UeSfp7jNZK
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Mashup Score: 5Journal Watch - 1 year(s) ago
The best critical care literature, updated daily
Source: criticalcarereviews.comCategories: Critical Care, Latest HeadlinesTweet-
Cardioprotective Strategies After Ischemia–Reperfusion Injury CCR Journal Watch https://t.co/Sp06oA6IDG Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at https://t.co/nitMzacLrj https://t.co/J6aetKcfM6
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Mashup Score: 12Journal Watch - 1 year(s) ago
The best critical care literature, updated daily
Source: criticalcarereviews.comCategories: Critical Care, Latest HeadlinesTweet-
The Unique Relationship between Neuro-Critical Care and Critical Illness-Related Corticosteroid Insufficiency CCR Journal Watch https://t.co/Sp06oA6IDG Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at https://t.co/nitMzacLrj https://t.co/AComUNrQXa
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Mashup Score: 9Journal Watch - 1 year(s) ago
The best critical care literature, updated daily
Source: criticalcarereviews.comCategories: Critical Care, Latest HeadlinesTweet-
End organ perfusion and pediatric microcirculation assessment CCR Journal Watch https://t.co/Sp06oA6IDG Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at https://t.co/nitMzacLrj https://t.co/WmeWwFEPC5
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Mashup Score: 5
This randomized clinical trial assesses the effect of administration of prophylactic amoxicillin-clavulanate vs placebo on 60-day mortality in patients hospitalized with severe alcohol-related hepatitis.
Source: jamanetwork.comCategories: Critical Care, Latest HeadlinesTweet-
What's the right way to report under-powered trials with neutral findings on efficacy? Seems like maybe not like this? https://t.co/pfQOXFhGN3
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Mashup Score: 17Journal Watch - 1 year(s) ago
The best critical care literature, updated daily
Source: criticalcarereviews.comCategories: Critical Care, Latest HeadlinesTweet-
Mechanism of heart failure after myocardial infarction CCR Journal Watch https://t.co/Sp06oA6IDG Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at https://t.co/nitMzacLrj https://t.co/sfzotFlEuU
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Mashup Score: 9Journal Watch - 1 year(s) ago
The best critical care literature, updated daily
Source: criticalcarereviews.comCategories: Critical Care, Latest HeadlinesTweet-
Practical points of hemoperfusion in the intensive care unit CCR Journal Watch https://t.co/Sp06oA6IDG Get the latest critical care literature every weekend via the CCR Newsletter - subscribe at https://t.co/nitMzacLrj https://t.co/xw9pWmnSeC
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#CritCare #OpenAccess Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction Read the full article: https://t.co/2r8GybtVUI @jlvincen @ISICEM #FOAMcc #FOAMed https://t.co/00dY6Xq5gR