Although intellectual humility is a prerequisite for credible science, it is rarely practised. Hoekstra and Vazire make recommendations on how to increase intellectual humility in research articles and highlight the crucial role of peer reviewers in promoting intellectually humble manuscripts.
Androgen receptor signaling is crucial for the development of treatment resistance in prostate cancer. Among steroidogenic enzymes, 3β-hydroxysteroid dehydrogenases (3βHSDs) play critical roles in extragonadal…
Alicia Morgans and Nima Sharifi discuss the role of the HSD3B1 gene and its variants in prostate cancer. Dr. Sharifi explains that the adrenal permissive…
The Nobel Prize winner Daniel Kahneman insisted on the value of working with those we disagree with.
© 2022. Producido por Zafiro/Novola en el año de 1971.Joan Manuel Serrat – Mediterráneo (1971)#joanmanuelserrat #Medierráneo #WMMusicRecordsLetra:Quizás porq…
The adrenal androgen-metabolizing 3β-hydroxysteroid dehydrogenase-1 enzyme, encoded by the HSD3B1 gene, catalyzes the rate-limiting step necessary for synthesizing nontesticular testosterone and dihydrotestosterone production.
Cancer-specific mortality twice as high in patients with specific genotype for HSD3B1 allele
This cohort study analyzes the association of HSD3B1 status with prostate cancer outcomes among patients in the Veterans Affairs Health System in the US.
Prostate cancer progression is dependent on androgen receptor signaling, which is activated by the circulating gonadal androgen testosterone and its more potent metabolite, 5α-dihydrotestosterone (DHT),…
Diverse data from the Million Veteran Program has already contributed to hundreds of medical studies, and the V.A. is continuing to recruit more participants.
