Article Commentary: “LDL-c Lowering, Ischemic Stroke, and Small Vessel Disease Brain Imaging Biomarkers”
A Mendelian randomization (MR) study is a design that aims to provide evidence about putative causal relations between modifiable risk factors and disease, using genetic variants as natural experiments. This method is l ess susceptible to confounders compared to other observational studies. This study investigates the association between genetically predicted LDL-c, subtypes of ischemic stroke and imaging biomarkers — perivascular spaces (PVS) and white matter hyperintensity (WMH) volumes — in a two-sample
