A Lipid Map for Community-acquired Pneumonia with Sepsis: Observation Is the First Step in Scientific Progress
Community-acquired pneumonia (CAP) with sepsis leads to over 350,000 ICU admissions in the United States annually, with an in-hospital mortality of 17% and a 1-year mortality of nearly 50% (1). There is an unmet need to disentangle the molecular processes that determine disease severity and drive adverse outcomes (2). The NHLBI has called for the use of biologic “omics” profiles to develop relevant “riskomes” for pneumonia to understand the pathobiology of host susceptibility to severe disease (3).