Deciphering the Pathobiological Impairment Mechanisms of the Lymphatic System during Secondary Lymphedema Progression
Secondary lymphedema resulting from oncologic treatment presents one of the most frequent, however underestimated complications of oncologic surgery. It is nowadays a common understanding that the lymphatic insult presents the trigger of a number of reactions, leading eventually to lymphedema onset and progression. Importantly, though, the triggering lymphatic insult does not present the sole cause of lymphedema, as such would correspondingly imply a “stop-cork” mechanism upon the lymphatic Despite