Despite significant improvement in clinical outcomes of chronic lymphocytic leukemia (CLL), patients who experience failure of Bruton tyrosine kinase inhibitors or venetoclax benefit from immune therapy approaches. Allogeneic transplant is a potentially curative treatment of CLL but is associated with risk of morbidity and mortality. Although still experimental, chimeric antigen receptor T-cell…
The use of T cells expressing chimeric antigen receptors (CARs) that can target and eliminate cancer cells has revolutionized the treatment of B-cell malignancies. In…
rnal tandem duplications (ITDs). Recent advances in the pathogenesis and biology of FLT3-mutated AML have opened an opportunity for development and application of selective inhibition…
This review discusses advances in evidence-based treatment of acute myeloid leukemia with molecularly targeted drug therapy.
