The Best of AACR Journals The Best of AACR Journals
The Best of the AACR Journals: 2021 edition
The Best of the AACR Journals: 2021 edition
Sotorasib and other selected KRASG12C inhibitors leverage differential dependence on switch-II pocket binding at amino acid position 95 to target all RASG12C isoforms, which has…
Summary:. In this issue, Rubinson, Tanaka, and colleagues demonstrate that differences among G12C inhibitors rely on their ability to covalently bind not only G12C mutant…
In this study, Rubinson, Tanaka, and colleagues reveal that a subset of switch-II pocket-binding KRASG12C inhibitors can target all RASG12C proteins. In contrast to KRASG12C-specific…
Sotorasib and other selected KRASG12C inhibitors leverage differential dependence on switch-II pocket binding at amino acid position 95 to target all RASG12C isoforms, which has…
Cancer Discovery | 14 | 5 | May 2024
Summary:. Spatial biology approaches enabled by innovations in imaging biomarker platforms and artificial intelligenceāenabled data integration and analysis provide an assessment of patient and disease…
AbstractPancreatic ductal adenocarcinoma (PDAC) therapeutic resistance is largely attributed to a unique tumor microenvironment embedded with an abundance of cancer-associated fibroblasts (CAF). Distinct CAF populations…
AbstractThe tumor microenvironment (TME) profoundly influences tumorigenesis, with gene expression in the breast TME capable of predicting clinical outcomes. The TME is complex and includes…
Abstract. Gain-of-function mutations in the histone acetylation āreaderā ENL, found in AML and Wilms tumor, are known to drive condensate formation and gene activation in…
Summary: . Pathogenic shifts in the gut microbiota are part of the āecologicalā alterations that accompany tumor progression and compromise immunosurveillance. The future management of…