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AUA Scientific Spotlight: Friday Edition
New to AUA this year – P2’s. These paradigm shifting, practice-changing clinical trials in urology are designed to showcase the exceptional groundbreaking st…
Digestive Disease Week
Explore special articles published online first to coincide with presentations at the American Psychiatric Association Annual Meeting.
Digestive Disease Week
Explore special articles published online first to coincide with presentations at the American Psychiatric Association Annual Meeting.
Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel
Allosteric modulation of pentameric ligand-gated ion channels (pLGICs) is critical to the action of neurotransmitters and many psychoactive drugs. However, details of their modulatory mechanisms…
Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM
Homotropic cooperativity is widespread in biological regulation. The homo-oligomeric ring-shaped trp RNA binding attenuation protein (TRAP) from bacillus binds multiple tryptophan ligands (Trp) and becomes…
Multilevel irreversibility reveals higher-order organisation of non-equilibrium interactions in human brain dynamics
Information processing in the human brain can be modelled as a complex dynamical system operating out of equilibrium with multiple regions interacting nonlinearly. Yet, despite…
High-Resolution Epitope Mapping for Glycosylated Antigens: Pembrolizumab-PD1 as a Case Study
High-resolution epitope mapping is important for in-depth activity assessment of antibodies and understanding of their functions, however, glycosylated antigens are challenging for many methods including…
Quantification of Trypanosoma Brucei social motility indicates different colony growth phases
In vitro colonies of the flagellated parasite Trypanosoma brucei grow in characteristic fingering instability patterns. The underlying cause of this this type of collective migration…
Adaptive optical third-harmonic generation microscopy for in vivo imaging of tissues
Third-harmonic generation microscopy is a powerful label-free nonlinear imaging technique, providing essential information about structural characteristics of cells and tissues without requiring external labelling agents.…
Salmonids exhibit an acute behavioral response to heterothermal environments
Most fish species are ectothermic and rely on behavioral strategies to control their body temperature in heterothermal environments. Both thermotaxis and thermokinesis have been suggested…