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Mashup Score: 57TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti–PD-1 tumor immunotherapy - 2 day(s) ago
PD-1 blockade in the absence of TREM2 biases gut macrophages and microbiota toward inflammatory programs and enhances tumor control.
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Mashup Score: 119Contents | Science Immunology 9, 95 - 3 day(s) ago
ONLINE COVER NK Cells Enforce a T Cell Checkpoint. Natural killer (NK) cells can eliminate infected or malignant cells, but how and when NK cell cytolytic activity is directed against host immune cells is not fully understood. Kilian et al. found that the expression of the NKp30 ligand B7H6 by activated human T cells promoted their cytolysis by NKp30 + NK cells. NK cells restricted the antitumor activity of B7H6 + chimeric antigen receptor (CAR) T cells and were associated with poor immunotherapy responses
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Mashup Score: 119
Carbonyl adducts of nucleobases are MR1-presented self-antigens recognized by T cells.
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Mashup Score: 76Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity - 4 day(s) ago
CAR T cells display distinctive profiles and actions in patients with CNS autoimmunity.
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Mashup Score: 64A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression - 5 day(s) ago
Tumor-derived lactate drives mregDC development and immunotolerant function by activating a SREBP2-dependent transcriptional program.
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Mashup Score: 113
Carbonyl adducts of nucleobases are MR1-presented self-antigens recognized by T cells.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
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Mashup Score: 75Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity - 8 day(s) ago
CAR T cells display distinctive profiles and actions in patients with CNS autoimmunity.
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Mashup Score: 62A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell maturation and promotes cancer progression - 9 day(s) ago
Tumor-derived lactate drives mregDC development and immunotolerant function by activating a SREBP2-dependent transcriptional program.
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Mashup Score: 38Oxidative phosphorylation regulates B cell effector cytokines and promotes inflammation in multiple sclerosis - 10 day(s) ago
OXPHOS-derived ATP and its metabolites modulate the balance of B cell cytokines in health and disease.
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Mashup Score: 68A TH17-intrinsic IL-1β–STAT5 axis drives steroid resistance in autoimmune neuroinflammation - 11 day(s) ago
IL-1β mediates steroid resistance in TH17 cells via a STAT5-dependent mechanism during autoimmune CNS inflammation.
Source: www.science.orgCategories: General Medicine News, Allergy-ImmunologyTweet
The combination of #TREM2 deficiency and #anti-PD1 #immunotherapy reprograms gut bacteria to support #tumor rejection in mice. @TheColonnaLab Learn more: https://t.co/Z9dxQLvCGT https://t.co/O40YLTMTcP