-
Mashup Score: 0
An 83-year-old man presented with IgD-λ–positive dysproteinemia complicated by rapidly progressive renal failure requiring periodic dialysis. Kidney biopsy revealed light chain cast nephropathy complicated by proximal tubulopathy (Supplemental Figure 1, available online at http://www.mayoclinicproceedings.org). Cast formation was prominent in the distal tubules and was not stained by periodic acid-Schiff (Figure A) but was stained red by hematoxylin-eosin (Figure B) and red and blue by Masson trichrome (Figure C).
Source: www.mayoclinicproceedings.orgCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 0
Female stress urinary incontinence, the loss of urine with transient increases in abdominal pressure, is a common condition that can profoundly impact a patient’s quality of life. The diagnosis is most commonly made via clinical history, including the subjective degree of bother, and physical examination evidence of urinary leakage with cough or Valsalva maneuver. A variety of treatment options exist for stress incontinence, ranging from observation, pelvic floor physical therapy, vaginal inserts, or continence pessaries to procedural interventions.
Source: www.mayoclinicproceedings.orgCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 0
The Androgen Society is an international, multidisciplinary medical organization committed to advancing research and education in the field of testosterone deficiency and testosterone therapy (TTh). This position paper is written in response to results of the TRAVERSE study, published in June 2023, which reported no increased risk of major adverse cardiovascular events (MACE) in men who received TTh compared with placebo.In 2013-2014, 2 observational studies reported increased cardiovascular (CV) risks with TTh and received wide media attention.
Source: www.mayoclinicproceedings.orgCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 0
The new United States Preventive Services Task Force (USPSTF) grade “B” recommendation for “average risk” women to get mammography screening every 2 years between 40 and 74 years of age simplifies the ongoing discussion about breast cancer screening as compared with the 2016 guidelines.1 The previous guideline was complicated and difficult to follow by primary care clinicians. However, before finalization, grounding the guideline discussion in the long held and increasingly accepted conviction that risk–rather than age-based screening–will improve outcomes results in lost opportunities is crucially important.
Source: www.mayoclinicproceedings.orgCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 0Unusual Osteoclast-like Plasma Cells in a Case of IgA Lambda Light Chain-Restricted Myeloma - 9 day(s) ago
A male in his mid-60s with immunoglobulin A lambda light chain–restricted multiple myeloma with a “normal” karyotype and plasma cell fluorescence in situ hybridization was treated with bortezomib, lenalidomide, and dexamethasone for 3.5 months with 1 month of daratumumab added with partial response. He underwent autologous peripheral blood stem cell transplantation. The day-58 bone marrow biopsy showed residual plasma cell myeloma with ∼15% light chain–restricted plasma cells showing many enlarged cells with numerous monomorphic and uniformly sized small round bland-appearing nuclei without Dutcher bodies or prominent nucleoli (Figures A and B).
Source: www.mayoclinicproceedings.orgCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 0Impact of Cardiorespiratory Fitness on COVID-19–Related Outcomes: The Exercise Testing and Health Outcomes Study (ETHOS) - 9 day(s) ago
To assess the association between cardiorespiratory fitness (CRF) and COVID-19–related health outcomes including mortality, hospitalization, and mechanical ventilation.
Source: www.mayoclinicproceedings.orgCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 0Increased Risk of New-Onset Hypertension in Patients With Narcolepsy Initiating Sodium Oxybate: A Real-World Study - 9 day(s) ago
To compare intermediate-term risk of new-onset hypertension between normotensive patients with narcolepsy initiating sodium oxybate (SXB cohort) and those not initiating sodium oxybate (control cohort).
Source: www.mayoclinicproceedings.orgCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 2Highly Cited Authors: Tait Shanafelt 2024 - 10 day(s) ago
Hematologist Jeanie and Stew Ritchie Professor of Medicine Chief Wellness Officer, Stanford Medicine Associate Dean, Stanford School of Medicine, Stanford Medicine Stanford, California This year, Tait Shanafelt, MD, was honored with a Mayo Clinic Proceedings highly cited author award. This award was developed to acknowledge articles for their meaningful contribution to the Journal’s latest Impact Factor. This highly cited manuscript received enough citations to place it in the top 1% of the academic
Source: www.mayoclinicproceedings.orgCategories: General Medicine News, General HCPsTweet
-
Mashup Score: 0Retroperitoneal Lymphadenopathy in a Patient With a History of Multiple Primary Malignant Neoplasms - 10 day(s) ago
An older man presented with retroperitoneal lymphadenopathy, mildly elevated β-human chorionic gonadotropin level, and a complex past medical history. Previous germline testing confirmed the presence of a pathogenic BRCA1 variant. Specifically, he had a past medical history of chronic myeloid leukemia, colorectal carcinoma, melanoma, seminoma, and prostate cancer. A retroperitoneal lymph node biopsy was performed, and histologic and immunohistochemical evaluation demonstrated metastasis from the patient’s previously diagnosed seminoma (Figure).
Source: www.mayoclinicproceedings.orgCategories: General Medicine News, General Journals & SocietTweet
-
Mashup Score: 0Evaluation and Management of Female Stress Urinary Incontinence - 10 day(s) ago
Female stress urinary incontinence, the loss of urine with transient increases in abdominal pressure, is a common condition that can profoundly impact a patient’s quality of life. The diagnosis is most commonly made via clinical history, including the subjective degree of bother, and physical examination evidence of urinary leakage with cough or Valsalva maneuver. A variety of treatment options exist for stress incontinence, ranging from observation, pelvic floor physical therapy, vaginal inserts, or continence pessaries to procedural interventions.
Source: www.mayoclinicproceedings.orgCategories: General Medicine News, General HCPsTweet
Medical image: Very likely, the first reported case of simultaneous occurrence of monoclonal gammopathy of undetermined significance and IgD-λ light chain proximal tubulopathy complicated by crystalline cast nephropathy. https://t.co/JvADl9oXfk https://t.co/MX9J5gZLtl