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Mashup Score: 53
This qualitative study assesses the quality, amount of active ingredient, and characteristics associated with counterfeiting of semaglutide purchased from illegal online pharmacies without a prescription.
Source: jamanetwork.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 71Navigating Drug Interactions with Proton Pump Inhibitors - 2 month(s) ago
With more than 113 million prescriptions dispensed annually, proton pump inhibitors (PPIs) are one of the most frequently prescribed drug classes worldwide.1 Despite their widespread use, often in combination with other medications, the potential involvement of PPIs in drug interactions is not…
Source: jamanetwork.comCategories: General Medicine News, General HCPsTweet-
If you're looking for a review of drug interactions with PPIs, @CarolynTanMD and I have you covered. Largest effects? Impaired absorption. https://t.co/2C5TrCm478 https://t.co/mt5uJsrq4b
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Mashup Score: 10Tox and Hound - We Need to Talk About Charcoal - 3 month(s) ago
by David Juurlink We need to talk about activated charcoal. Why? Because we sometimes give it when we probably shouldn’t, and we sometimes don’t when we
Source: toxandhound.comCategories: General Medicine News, General HCPsTweet-
When should you give activated charcoal? I’ve shared this old post a lot recently because people seem to focus too much on timing. https://t.co/wOHjwzg1pG https://t.co/SpsgYz0Wvg
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Mashup Score: 58
Perioperative corticosteroids have shown potential as non-opioid analgesic adjuncts for various orthopedic pathologies, but there is a lack of research on their use in the postoperative setting after total shoulder arthroplasty (TSA). The purpose of this study was to assess the effect of a methylprednisolone taper on a multimodal pain regimen after TSA.
Source: www.jshoulderelbow.orgCategories: General Medicine News, General HCPsTweet-
Take a look at what a few days of low-dose, tapering methylprednisolone does to pain and opioid consumption following shoulder surgery. https://t.co/3GNBXxoIu2 https://t.co/jJXClOeXtE
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Mashup Score: 29Modafinil Treatment of Opioid-Induced Sedation - 4 month(s) ago
ABSTRACT. Study Objective. The purpose of this study was to assess the efficacy of modafinil in combating opioid-induced sedation.Design. A 1-year retrospe
Source: academic.oup.comCategories: General Medicine News, General HCPsTweet-
Reminded today about this 2003 study suggesting that modafinil could combat opioid-induced sedation, allowing an increase in the average daily dose from 536 MME to 810 MME Or as we'd call it in 2024: malpractice https://t.co/Zh3XNFNCjG https://t.co/sKwGLsqVAK
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Mashup Score: 19Academic Clinical Immunologist/Allergist or Clinical Pharmacologist - 4 month(s) ago
Academic Clinical Immunologist/Allergist or Clinical Pharmacologist
Source: jobs.utoronto.caCategories: General Medicine News, General HCPsTweet-
Are you an academic physician with expertise in the evaluation of adverse drug reactions? Would you like to live and work in Toronto? We are looking for two such people. Postings below. RTs appreciated. https://t.co/NIDjXMte3x https://t.co/JZzPPN1VJQ https://t.co/N65kMZwyku
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Mashup Score: 4
American Journal of Cardiovascular Drugs – The renin–angiotensin–aldosterone system plays an important role in the pathophysiology of hypertension and is closely related with cardio-…
Source: link.springer.comCategories: General Medicine News, General HCPsTweet-
@drjohnm There’s no “one best ARB”; choice depends on the patient (eg. gout? telmisartan). Useful review here https://t.co/yr24EfrZUd
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Mashup Score: 17Concentration-Dependent Mode of Interaction of Angiotensin II Receptor Blockers with Uric Acid Transporter - 5 month(s) ago
Serum uric acid (SUA) is currently recognized as a risk factor for cardiovascular disease. It has been reported that an angiotensin II receptor blocker (ARB), losartan, decreases SUA level, whereas other ARBs, such as candesartan, have no lowering effect. Because the renal uric acid transporter (URAT1) is an important factor controlling the SUA level, we examined the involvement of URAT1 in those differential effects of various ARBs on SUA level at clinically relevant concentrations. This study was done by using URAT1-expressing Xenopus oocytes. Losartan, pratosartan, and telmisartan exhibited cis -inhibitory effects on the uptake of uric acid by URAT1, whereas at higher concentrations, only telmisartan did, and these ARBs reduced the uptake in competitive inhibition kinetics. On the other hand, candesartan, EXP3174 [2- n -butyl-4-chloro-1-[(2′-(1 H -tetrazol-5-yl)biphenyl-4-yI)methyl]imidazole-5-carboxylic acid] (a major metabolite of losartan), olmesartan, and valsartan were not in
Source: jpet.aspetjournals.orgCategories: General Medicine News, General HCPsTweet-
Worth noting that telmisartan and losartan have comparable effects on UA uptake https://t.co/dpdCVHzUEq https://t.co/W4hZH14k1H
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Mashup Score: 50Effect of the single CYP2C9*3 allele on pharmacokinetics and pharmacodynamics of losartan in healthy Japanese subjects - 5 month(s) ago
European Journal of Clinical Pharmacology – Losartan is metabolized to the active carboxylic acid metabolite EXP3174 by CYP2C9. In this study, we determined the effects of the single CYP2C9*3…
Source: link.springer.comCategories: General Medicine News, General HCPsTweet-
Unsurprisingly, CYP2C9 genotype influences the response to therapy. Even one copy of *3 undermines the hypotensive response to losartan. /5 https://t.co/TC9ldTKrbQ https://t.co/PoTc976MQQ
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Mashup Score: 45Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics - 5 month(s) ago
Acta Pharmacologica Sinica – Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics
Source: www.nature.comCategories: General Medicine News, General HCPsTweet-
CYP2C9*3 homozygotes (who essentially have no CYP2C9 activity) product almost no active metabolite. /4 https://t.co/ttAYOJAbBj https://t.co/FaiHs3wSRF
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It you're buying Ozempic online without a prescription good luck with that https://t.co/d8QOrfaBd5 https://t.co/k5FvWWLQ4p