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Purpose: We report the intracranial efficacy of selpercatinib, a highly potent and selective RET inhibitor, approved in the United States for RET fusion-positive non–small...

Standard first-line chemotherapy for patients with small cell lung cancer (SCLC) consists of a platinum salt (carboplatin or cisplatin) in combination with etoposide [1,2]....

Results of an exploratory interim analysis from a phase I trial show that an RNA vaccine targeted towards four melanoma-associated antigens produces durable objective...

Pralsetinib is a new, well-tolerated, promising, once-daily oral treatment option for patients with RET fusion-positive...

Pralsetinib is a new, well-tolerated, potent once-daily oral treatment option for patients with RET-altered thyroid...

Initiatives such as The Cancer Genome Atlas and the International Cancer Genome Consortium has led to the identification of specific molecular drivers of human...