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Why nasal vaccines for Covid could be so...

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    It’s time to invest in next generation COVID vaccines that not only prevent severe disease but also block infection and transmission. It makes sense to induce mucosal immunity to fight a mucosal viral infection. My opinion in @nytimes today👇🏽 https://t.co/8iazYmf3sH - view on twitter

Three nasal spritzes, now in advanced trials, could trigger stronger immunity than shots in the...

SARS-CoV-2 variants of concern (VOCs) possess mutations that confer resistance to neutralizing antibodies within the Spike protein and are associated with breakthrough infection and...

Certain acute infections (including SARS-CoV-2) are associated with an unexplained chronic disability in a minority of patients; this Review summarizes what is known about...

The cell surface display of peptides by MHC class I molecules to lymphocytes provides the host with an important surveillance mechanism to protect against...

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    CD8 T cells help fight off viral infection by detecting and killing infected cells. CD8 T cells detect MHC I + viral peptide on infected cells. One of the common tricks viruses use to avoid killing is to inhibit MHC I expression and presentation. (2/) https://t.co/wulbfhDYpH - view on twitter

In a recent study posted to the bioRxiv* pre-print server, researchers demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants did not evolve...

The improper timing of transforming growth factor-β production is a hallmark of severe COVID-19 that may impede natural killer cell function and early control...

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    If SARS-CoV-2 is so capable of shutting down MHC I, why aren’t the infected cells detected by natural killer (NK) cells and killed? In mild cases, possibly yes. In severe COVID patients, untimely production of TGFβ inhibits NK antiviral function. (14/) https://t.co/wjWvyueTRR - view on twitter

The presentation of viral antigens to T cells via the MHC molecules is a critical component of the host response to viral infection. Here...

Sobered by the way the omicron variant tore through the population — including the vaccinated — some scientists think the next coronavirus vaccine should...

AAI Council Member Dr. Akiko Iwasaki (AAI ’00), whose lab studies immune responses to mucosal viruses and cancer, reflects on why she loves the...