Mashup Score:4045
New York TimesOpinion | The Answer to Stopping the Coronavirus May Be Up the Nose - 1 week
Mashup Score:4045
Twitter Feed: Prof. Akiko Iwasaki
Mashup Score:1063
Scientific AmericanNose Spray Vaccines Could Quash COVID Virus Variants - 3 weeks
Mashup Score:1063
Three nasal spritzes, now in advanced trials, could trigger stronger immunity than shots in the...
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RT @sciam: Nose Spray Vaccines Could Quash COVID Virus Variants https://t.co/b3Htatq4Vp - view on twitter
Mashup Score:922
bioRxivSARS-CoV-2 variants do not evolve to promote further escape from MHC-I recognition - 3 weeks
Mashup Score:922
SARS-CoV-2 variants of concern (VOCs) possess mutations that confer resistance to neutralizing antibodies within the Spike protein and are associated with breakthrough infection and...
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In this study, @MiyuMoriyama et al investigate how well SARS-CoV-2 variants of concern (VOC) suppress MHC I needed for recognition by cytotoxic T cells. This question is important to understand how well the virus limits CD8 killing 🧵(1/) @biorxivpreprint https://t.co/TLvnB7NotN https://t.co/TLvnB7NotN - view on twitter
Mashup Score:842
NatureUnexplained post-acute infection syndromes – Nature Medicine - 7 days
Mashup Score:842
Certain acute infections (including SARS-CoV-2) are associated with an unexplained chronic disability in a minority of patients; this Review summarizes what is known about...
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Please read our latest review by @jan_choutka et al. on “Unexplained post-acute infection syndromes”. What a privilege to work with Jan Choutka, who is an #MECFS patient, expert and advocate. Grateful to @mhornig on her expertise/insights 🙏🏼 (1/) https://t.co/eLuuCObuse - view on twitter
More coverage:
#mecfs
Mashup Score:198
PubMedMHC class I antigen presentation: learning from viral evasion strategies – PubMed - 3 weeks
Mashup Score:198
The cell surface display of peptides by MHC class I molecules to lymphocytes provides the host with an important surveillance mechanism to protect against...
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CD8 T cells help fight off viral infection by detecting and killing infected cells. CD8 T cells detect MHC I + viral peptide on infected cells. One of the common tricks viruses use to avoid killing is to inhibit MHC I expression and presentation. (2/) https://t.co/wulbfhDYpH - view on twitter
Mashup Score:190
News-Medical.netSARS-CoV-2 variants are not evolving to escape from T cell-mediated immunity - 3 weeks
Mashup Score:190
In a recent study posted to the bioRxiv* pre-print server, researchers demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants did not evolve...
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In writing this thread, I found this nice summary of our work by Neha Mathur. (13/) https://t.co/zH92d6hC7P - view on twitter
Mashup Score:186
NatureUntimely TGFβ responses in COVID-19 limit antiviral functions of NK cells – Nature - 3 weeks
Mashup Score:186
The improper timing of transforming growth factor-β production is a hallmark of severe COVID-19 that may impede natural killer cell function and early control...
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If SARS-CoV-2 is so capable of shutting down MHC I, why aren’t the infected cells detected by natural killer (NK) cells and killed? In mild cases, possibly yes. In severe COVID patients, untimely production of TGFβ inhibits NK antiviral function. (14/) https://t.co/wjWvyueTRR - view on twitter
Mashup Score:144
NatureThe presentation of viral antigens to T cells via the MHC molecules is a critical component of the host response to viral infection. Here...
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A nice study by Yoo et al showed that SARS-CoV-2 suppresses mRNA expression of MHC I by targeting the STAT1-IRF1-NLRC5 axis. https://t.co/96Y73kbtwN Indeed, all MHC I mRNA was down-regulated by all viral strains except for the P.1 variant. But VOCs were no better than WA1. (5/) https://t.co/96Y73kbtwN - view on twitter
Mashup Score:129
Washington PostThe next leap in coronavirus vaccine development could be a nasal spray - 1 month
Mashup Score:129
Sobered by the way the omicron variant tore through the population — including the vaccinated — some scientists think the next coronavirus vaccine should...
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An excellent piece on why we should be looking to nasal spray as the future of COVID booster vaccines by @Carolynyjohnson @NIAIDNews please include our Prime and Spike in the upcoming vaccine bake-off 🥺 https://t.co/mV46hpb5LR - view on twitter
Mashup Score:102
YouTubeAsian American and Pacific Islander Heritage Month: Akiko Iwasaki, Ph.D., Yale Univ. Sch. of Med. - 3 weeks
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AAI Council Member Dr. Akiko Iwasaki (AAI ’00), whose lab studies immune responses to mucosal viruses and cancer, reflects on why she loves the...
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I am happy to celebrate #AAPIHeritageMonth. In this video for @ImmunologyAAI, I answered the question, “Why do you choose to work in immunology?" Thank you AAI for highlighting AAPI immunologists 🙏🏼 (Background photos courtesy of @portefeuillefun) https://t.co/LsBrPP1kR2 https://t.co/LsBrPP1kR2 - view on twitter
More coverage:
#aapiheritagemonth
Why nasal vaccines for Covid could be so...
It’s time to invest in next generation COVID vaccines that not only prevent severe disease but also block infection and transmission. It makes sense to induce mucosal immunity to fight a mucosal viral infection. My opinion in @nytimes today👇🏽 https://t.co/8iazYmf3sH - view on twitter