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A third dose of an mRNA vaccine against SARS-CoV-2 results in an expanded B cell repertoire that produces antibodies with increased potency and...

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    This paper shows us that a booster expand B cell potency and breadth & would target our yearly booster campaign to older people, those on immunosuppressants, those with comorbidities to increase uptake in those who need most https://t.co/neVzbuWDNw - view on twitter

Sequencing of B cell receptors and expression of the corresponding monoclonal antibodies is used to characterize the evolution of the long-term B cell response to...

The extraordinary absence of RSV during winter 2020–21 probably resulted in a cohort of young children without natural immunity to RSV, thereby raising the...

Older people, those with multimorbidity, and those with specific underlying health conditions remain at increased risk of COVID-19 hospitalisation and death after the initial...

The FDA has authorised bivalent booster vaccines containing mRNA for the ancestral SARS-CoV-2 variant as well as B.1.1.529.4 (BA.4) and B.1.1.529.5 (BA.5), the latter...

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    Boosters don't raise IgA (mucosal Ab) in nose to prevent every infection (so can't prevent case increases- last year's booster campaign showed us this) but can protect those who need elevated IgG (blood Ab) when confronting virus (such as older people) https://t.co/YJzM7W4g3G - view on twitter

Mashup Score:39

Medscape

COVID vaccines are said to “wane” in efficacy but that refers to only one arm of the immune...

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    For immunocompromised, mRNA vaccines work well due to 1) high amounts of protein made to which to raise immune response; 2) redundancy of immune system. Paxlovid for very vulnerable. RNA viruses leave body unlike retroviruses; Mental health matters https://t.co/YmaUhymVXl - view on twitter

Mashup Score:35

Medscape

How Does Cellular Immunity Work? - 6 days

Mashup Score:35

Cellular immunity and antibodies are both key to the vaccine and booster response for...

Thomas and colleagues describe how multiple SARS-CoV-2 antigen exposures, including mRNA vaccine boosters, primary infection and breakthrough infection, shape T cell...

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    This paper shows us that T cells diversity and expand with each exposure to the virus, consistent with decades of research showing us how the immune system works when confronted with other RNA viruses (& other coronaviruses) https://t.co/FDd8jTYWJW - view on twitter

Researchers say there is a growing body of evidence these viruses interfere with each other’s...

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    VIRAL INTERFERENCE: Idea here is that viruses interfere with each other (hard to be co-infected with two at same time, not impossible) explaining why RSV, influenza rose as COVID abates with high population immunity; viruses compete with each other https://t.co/GakJnRjZ49 - view on twitter