Mashup Score:335
NatureIncreased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost – Nature - 7 days
Mashup Score:335
Twitter Feed: Monica Gandhi MD, MPH
Mashup Score:162
NatureGerminal centre-driven maturation of B cell response to mRNA vaccination – Nature - 7 days
Mashup Score:162
Sequencing of B cell receptors and expression of the corresponding monoclonal antibodies is used to characterize the evolution of the long-term B cell response to...
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T/B cells protect from severe disease but how do we know B cells in memory? Because in the plethora of papers out of COVID, 2 emerge as gems. Below shows SARS-CoV-2 B cells in bone marrow after infection. This shows memory B cells in lymph nodes after vax https://t.co/si7tuAPwPi https://t.co/si7tuAPwPi - view on twitter
Mashup Score:73
MedscapeLong-acting Treatment and Prevention of HIV Are Here - 4 days
Mashup Score:73
Advances in long-acting treatment and prevention for HIV are changing the way we treat our...
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Very exciting time for long-acting prevention and HIV treatment: https://t.co/0cZeAhQUPc - view on twitter
The extraordinary absence of RSV during winter 2020–21 probably resulted in a cohort of young children without natural immunity to RSV, thereby raising the...
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IMMUNITY "DEBT" seems to be evolving term for the effect of NPIs for COVID on leading to more severe infections later of other types (think also viral interference, as COVID recedes): PNAS paper below & Lancet ID article here (both top journals): https://t.co/apZCdpEjIT https://t.co/apZCdpEjIT - view on twitter
Older people, those with multimorbidity, and those with specific underlying health conditions remain at increased risk of COVID-19 hospitalisation and death after the initial...
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Who is risk of severe disease with re-infection after 2 vax doses? Google "Lancet 30 million UK" to find largest study looking at question; link here: https://t.co/d59GiAajp2 Groups need boosters/Paxlovid; Sober, data-based approaches to pandemic like in EU/UK will win the day https://t.co/d59GiAajp2 - view on twitter
Mashup Score:44
The Lancet Infectious DiseasesNew boosters are here! Who should receive them and when? - 7 days
Mashup Score:44
The FDA has authorised bivalent booster vaccines containing mRNA for the ancestral SARS-CoV-2 variant as well as B.1.1.529.4 (BA.4) and B.1.1.529.5 (BA.5), the latter...
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Boosters don't raise IgA (mucosal Ab) in nose to prevent every infection (so can't prevent case increases- last year's booster campaign showed us this) but can protect those who need elevated IgG (blood Ab) when confronting virus (such as older people) https://t.co/YJzM7W4g3G - view on twitter
Mashup Score:39
MedscapeCOVID-19 Vaccines Work Better Than Expected - 2 days
Mashup Score:39
COVID vaccines are said to “wane” in efficacy but that refers to only one arm of the immune...
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For immunocompromised, mRNA vaccines work well due to 1) high amounts of protein made to which to raise immune response; 2) redundancy of immune system. Paxlovid for very vulnerable. RNA viruses leave body unlike retroviruses; Mental health matters https://t.co/YmaUhymVXl - view on twitter
Mashup Score:35
MedscapeHow Does Cellular Immunity Work? - 6 days
Mashup Score:35
Cellular immunity and antibodies are both key to the vaccine and booster response for...
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IMMUNOLOGY: This is because T cells from vaccine or natural infection cover variants or subvariants B cells generated by either produce antibodies directed against subvariant they see (adaptive) explanation here: https://t.co/1p2WlW9EkC https://t.co/1p2WlW9EkC - view on twitter
Mashup Score:31
NatureThomas and colleagues describe how multiple SARS-CoV-2 antigen exposures, including mRNA vaccine boosters, primary infection and breakthrough infection, shape T cell...
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This paper shows us that T cells diversity and expand with each exposure to the virus, consistent with decades of research showing us how the immune system works when confronted with other RNA viruses (& other coronaviruses) https://t.co/FDd8jTYWJW - view on twitter
Mashup Score:29
www.science.orgCompetition between respiratory viruses may hold off a ‘tripledemic’ this winter - 4 days
Mashup Score:29
Researchers say there is a growing body of evidence these viruses interfere with each other’s...
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VIRAL INTERFERENCE: Idea here is that viruses interfere with each other (hard to be co-infected with two at same time, not impossible) explaining why RSV, influenza rose as COVID abates with high population immunity; viruses compete with each other https://t.co/GakJnRjZ49 - view on twitter
A third dose of an mRNA vaccine against SARS-CoV-2 results in an expanded B cell repertoire that produces antibodies with increased potency and...
This paper shows us that a booster expand B cell potency and breadth & would target our yearly booster campaign to older people, those on immunosuppressants, those with comorbidities to increase uptake in those who need most https://t.co/neVzbuWDNw - view on twitter