MashupMD

Mashup Score:27

PubMed

Cardiovascular Benefit of Lowering Low-Density Lipoprotein Cholesterol Below 40 mg/dL – PubMed - 4 weeks

Mashup Score:27

Cardiovascular Benefit of Lowering Low-Density Lipoprotein Cholesterol Below 40...

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Sam Tsimikas, MD

The data do not suggest a risk, in fact, benefit seems to accrue even to LDL 20. https://t.co/IPUTA4tlx4 https://t.co/IPUTA4tlx4 https://t.co/IPUTA4tlx4 - view on twitter

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Mashup Score:9

YouTube

Lucy and the Chocolate Factory high res - 1 month

Mashup Score:9

...

1652344942390554625

Sam Tsimikas, MD

Because it is programmed to be made by the LPA gene. Its on "auto-pilot", unless you change or modify the genetic code, it will keep making x amount of Lp(a) per hour ad infinitum. It's Lucille Ball packing chocolates on the conveyor belt. https://t.co/trFTOcksmn https://t.co/trFTOcksmn - view on twitter

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Mashup Score:7

ScienceDirect

Medial Arterial Calcification: JACC State-of-the-Art Review - 1 month

Mashup Score:7

Medial arterial calcification (MAC) is a chronic systemic vascular disorder distinct from atherosclerosis that is frequently but not always...

1652893973449691136

Sam Tsimikas, MD

My point was "medial" calcification, not medical. Atheroscerosis occurs between the intima and media. Medial calcification is between the media and adventitia. See review article - https://t.co/jYciTMFU3l https://t.co/jYciTMFU3l https://t.co/jYciTMFU3l - view on twitter

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Mashup Score:5

PubMed

LDL isolated from Greek subjects on a typical diet or from American subjects on an oleate-supplemented diet induces less monocyte chemotaxis and adhesion when exposed to oxidative stress – PubMed - 1 month

Mashup Score:5

The mechanisms underlying the cardiovascular benefits of Mediterranean-style diets are not fully understood. The high content of monounsaturated fatty acids in Mediterranean-style diets derived...

1651624659698294788

Sam Tsimikas, MD

These are not very sensitive. I would like to see if lipoproteins are more oxidized, or have a higher propensity for being oxidized when loaded with EPA, this has not been studied. We showed when one replaces PUFA with MUFA, propensity diminishes. https://t.co/aFh9f2L775 https://t.co/aFh9f2L775 https://t.co/aFh9f2L775 - view on twitter

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Mashup Score:3

SpringerLink

Prevention and Treatment of Cardiovascular Disease - 4 weeks

Mashup Score:3

This book discusses all aspects of non-pharmacologic approaches to primary and secondary CVD prevention, including novel and emerging dietary...

1654861799710425090

Sam Tsimikas, MD

3/13 2. First, it is important to distinguish studies of macronutrients vs diet styles. There is clear evidence that plant-based diet styles can reduce CV risk, e.g. Med Diet, DASH https://t.co/0lzWArOH3L See chapter on Plant-Based Diets - view on twitter

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Mashup Score:3

Frontiers

Relationship between lipoprotein(a) and colorectal cancer among inpatients: a retrospective study - 3 days

Mashup Score:3

The present study was to explore the association between lipoprotein(a) [Lp(a)] and colorectal cancer (CRC) among inpatients. This study included 2822 participants (393 cases...

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Sam Tsimikas, MD

2/4 1- this study suggests ⏫ Lp(a) associated with colorectal cancer. Risk worse @ Lp(a) >30 mg/dL. Large sample size, but case control, so hypothesis generating, not proof. It will be interesting to see if Lp(a) lowering will affect cancer incidence. https://t.co/Y9OsYFNfeh https://t.co/Y9OsYFNfeh - view on twitter

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Mashup Score:3

ScienceDirect

Non-genetic influences on lipoprotein(a) concentrations - 4 weeks

Mashup Score:3

An elevated level of lipoprotein(a) [Lp(a)] is a genetically regulated, independent, causal risk factor for cardiovascular disease. However, the...

1654861810171015168

Sam Tsimikas, MD

10/13 9. For 2 great, contemporary reviews by Byambaa Enkhmaa and colleagues on this topic, see: https://t.co/LuL7lonuif https://t.co/LuL7lonuif - view on twitter

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Mashup Score:2

OUP Academic

Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial states - 4 weeks

Mashup Score:2

ABSTRACT. Background: In subjects with a high prevalence of metabolic risk abnormalities, the preferred replacement for saturated fat is unresolved.Objective:...

1654861805469175808

Sam Tsimikas, MD

7/13 6. The DELTA Program (1990’s, early 2000’s) examined replacement of SFA with other macronutrients, including effects on Lp(a): https://t.co/fWXLJDutBd https://t.co/fWXLJDutBd - view on twitter

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Mashup Score:2

PubMed

Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a) – PubMed - 1 month

Mashup Score:2

Oxidized phospholipids (OxPLs) are present on apolipoprotein (a) [apo(a)] and lipoprotein (a) [Lp(a)] but the determinants influencing their binding are not known. The presence...

1649423880619008006

Sam Tsimikas, MD

Interestingly, the hedgehog (African and European) has a variant Lp(a), it has multiple copies of Kringle III, not KIV (like monkeys) or KIV/V (like apes/humans). See: Saturday Morning Class #7 Lp(a) and kringles, and paper. @swissCTO https://t.co/ErTHPp6Og7 https://t.co/ErTHPp6Og7 https://t.co/ErTHPp6Og7 - view on twitter

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Mashup Score:2

PubMed

Prevalence and influence of LPA gene variants and isoform size on the Lp(a)-lowering effect of pelacarsen – PubMed - 1 month

Mashup Score:2

In patients randomized to Lp(a) lowering trials, LPA genetic variants are common, but a sizable proportion do not carry common variants associated with elevated...

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Sam Tsimikas, MD

Yes, most or LPA snps are not "causal", they are simply a "marker" to tell you the patient has small isoforms, i.e if A=B and B=C, then A=C. You can read about the percentages of LPA snps relative to isoform size in this paper we published. https://t.co/CHCpzS4VFN https://t.co/CHCpzS4VFN https://t.co/CHCpzS4VFN - view on twitter

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