EricTopol Archives

Mashup Score:679

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern - 2 days

Mashup Score:679

The durability of immune memory after SARS-CoV-2 mRNA vaccination remains unclear. Here, we longitudinally profiled vaccine responses in SARS-CoV-2 naïve and recovered individuals for...

Eric Topol

Just out @ScienceMagazine The memory B and T cell response to mRNA vaccines is quite durable and functional for at least 6 months, and for all the major variants, including Delta. https://t.co/r0nzAiWjnd (A very reassuring finding in light of short dose spacing of 3-4 weeks) https://t.co/r0nzAiWjnd - view on twitter

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Mashup Score:522

New England Journal of Medicine (NEJM)

Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines | NEJM - 22 hours

Mashup Score:522

Correspondence from The New England Journal of Medicine — Differential Kinetics of Immune Responses Elicited by Covid-19...

Eric Topol

Just published @NEJM Neutralizing antibody levels and T cells response out to 8 months for Pfizer, Moderna and J&J vaccines https://t.co/ghAgk3Y4kR Moderna highest antibody response; J&J while lower doesn't fall off and best CD8 T-cell response at 8 months https://t.co/ghAgk3Y4kR - view on twitter

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Mashup Score:377

medRxiv

Breakthrough SARS-CoV-2 infections in 620,000 U.S. Veterans, February 1, 2021 to August 13, 2021 - 2 days

Mashup Score:377

National data on COVID-19 vaccine breakthrough infections is inadequate but urgently needed to determine U.S. policy during the emergence of the Delta variant. We...

Eric Topol

New on breakthrough infections in 620,000 Veterans "Vaccine protection declined by mid-August 2021, decreasing from 91.9% in March to 53.9%" https://t.co/xonBb4aEqJ highest reduction with J&J vaccine https://t.co/xonBb4aEqJ - view on twitter

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Mashup Score:174

medRxiv

One-shot immunization with Sputnik Light (the first component of Sputnik V vaccine) is effective against SARS-CoV-2 Delta variant: efficacy data on the use of the vaccine in civil circulation in Moscow - 2 days

Mashup Score:174

Objectives Vaccination remains the most effective response to the COVID-19 pandemic. Most vaccines use two-dose regimens. In turn, single-dose vaccines also have high potential,...

Eric Topol

I find this hard to believe "Sputnik Light demonstrates higher efficacy against Delta variant than many two-shot vaccines." https://t.co/MRVRECX7YV - view on twitter

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Mashup Score:106

Cell

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes - 2 days

Mashup Score:106

PE4 and PE5 are efficient and precise prime editing systems developed by leveraging insights into the way DNA repair pathways impact genome editing...

Eric Topol

So you want to do genome editing more efficiently and at scale, for 1000s of bases? Cure tyrosinemia in mice? A very big 3-fer day for @davidrliu's prime editing https://t.co/HbTDWfhcU6 https://t.co/HbTDWfhcU6 @JShendure https://t.co/HbTDWfhcU6 @xue_lab https://t.co/HbTDWfhcU6 https://t.co/HbTDWfhcU6 - view on twitter

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Mashup Score:103

JAMA Network

Administration of Monoclonal Antibody for COVID-19 in Patient Homes - 2 days

Mashup Score:103

This cohort study examines the outcomes of a program providing monoclonal antibody treatments to COVID-19–positive patients in their...

Eric Topol

A new approach for giving intravenous infusions of monoclonal antibodies for Covid: home delivery https://t.co/ZT9ajvVd3Q - view on twitter

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Mashup Score:102

Science

Heuristics in the delivery room - 22 hours

Mashup Score:102

Doctors use simplified rules based on prior patient outcomes to guide birth delivery...

Eric Topol

How medicine is practiced You're about to deliver a baby. Does your obstetrician used the evidence base to decide on whether to do a C-section? No. It's largely driven by the last patient https://t.co/Te2U5xVkI1 https://t.co/Te2U5xVkI1 @ScienceMagazine @vini_singh_ https://t.co/Te2U5xVkI1 - view on twitter

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Mashup Score:94

The Lancet

Malaria vaccine approval: a step change for global health - 2 days

Mashup Score:94

On Oct 6, WHO announced that it will be recommending widespread use of the RTS,S/AS01 (RTS,S) malaria vaccine for children in sub-Saharan Africa and...

Eric Topol

Putting the malaria vaccine in perspective https://t.co/OHOxhD8E0e @TheLancet today's cover https://t.co/OHOxhD8E0e - view on twitter

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Mashup Score:89

medRxiv

Vaccine effectiveness against SARS‐CoV‐2 transmission to household contacts during dominance of Delta variant (B.1.617.2), August‐September 2021, the Netherlands - 2 days

Mashup Score:89

We estimated vaccine effectiveness against onward transmission by comparing secondary attack rates among household members between vaccinated and unvaccinated index cases, based on source...

Eric Topol

A new study from the Netherlands on Delta transmission to household contacts, w/ or w/o vaccination, adds to the one below. Delta spread is harder to suppress. https://t.co/dJn0hINngH Same group reported 73% VE vs transmission to unvaccinated household contacts for Alpha https://t.co/dJn0hINngH https://t.co/dJn0hINngH - view on twitter

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Mashup Score:77

Genome Medicine

Artificial intelligence enables comprehensive genome interpretation and nomination of candidate diagnoses for rare genetic diseases – Genome Medicine - 2 days

Mashup Score:77

Background Clinical interpretation of genetic variants in the context of the patient’s phenotype is becoming the largest component of cost and time expenditure for...

Eric Topol

How #AI and rapid whole genome sequencing is transforming the diagnosis of sick newborns https://t.co/SEphHx2FwY @RadyGenomics @radychildrens @ribozyme @FabricGenomics https://t.co/SEphHx2FwY - view on twitter

More coverage: #ai

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