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Background: Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are foundational therapy in patients with heart failure with reduced ejection fraction (HFrEF), yet underlying mechanisms of benefit...

Andrew A. GibbAndrew A. Gibb https://orcid.org/0000-0003-2770-430X Center for Translational Medicine, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA...

BACKGROUND: Supervised aerobic exercise training (ET) is recommended for stable outpatients with heart failure (HF) with reduced ejection fraction (HFrEF). Frailty, a syndrome characterized...

FootnotesReferences1. Keele KD. Leonardo da Vinci as physiologist.Postgrad Med J. 1952; 28:521–528. doi: 10.1136/pgmj.28.324.521CrossrefMedlineGoogle Scholar2. du Fay de Lavallaz J, Prepoudis A, Wendebourg MJ,...

Background:Despite the reduced incidence of coronary heart disease with intensive risk factor management, people with diabetes mellitus and prediabetes remain at increased coronary heart...

Background: Timely diagnosis of structural heart disease improves patient outcomes, yet many remain underdiagnosed. While population screening with echocardiography is impractical,...

Catherine A. Makarewich Correspondence to: Catherine A. Makarewich, PhD, Division of Molecular Cardiovascular Biology, Cincinnati Children’s Hospital Medical Center, 240 Albert Sabin Way, MLC...

Background: There are good data to support using a single high-sensitivity cardiac troponin T (hs-cTnT) below the limit of detection (LoD) of 5 ng/L...

BACKGROUND: Early neonates of both large and small mammals are able to regenerate the myocardium through cardiomyocyte proliferation for only a short period after...

Footnotes*M. Vaduganathan and B.L. Claggett contributed equally.This work was presented as an abstract at the European Society of Cardiology Heart Failure 2022 Scientific Congress,...