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Cancer Discovery - Mobocertinib, an oral epidermal growth factor receptor (EGFR) inhibitor targeting EGFR gene mutations including exon 20 insertions (EGFRex20ins) in non-small cell lung cancer, was...

Cancer Discovery - Despite a remarkable increase in the genomic profiling of cancer, integration of genomic discoveries into clinical care has lagged behind. We report the feasibility...

T-cell Receptor–Engineered T Cells Show Efficacy in HPV+ Carcinomas

posted 13 hours


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Cancer Discovery - A T-cell receptor T-cell therapy showed early promise in human papillomavirus (HPV)–linked...

Cancer Discovery - Mutations in IFN- and MHC-signaling genes endow immunotherapy resistance. Colorectal cancer patients infrequently exhibit IFN- and MHC-signaling gene mutations, and are generally resistant to...

Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer

posted 8 hours


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Cancer Discovery - Most epidermal growth factor receptor (EGFR) exon 20 insertion (EGFRex20ins) driver mutations in non-small cell lung cancer (NSCLC) are insensitive to approved EGFR tyrosine...

Continuous BAF Complex Function Is Required to Maintain Chromatin State

posted 6 hours


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Cancer Discovery - Disrupting the chromatin-remodeling BAF (SWI/SNF) complex’s function altered chromatin in...

Cancer Discovery - Colorectal cancer (CRC) is multi-faceted with subtypes defined by genetic, histological, and immunologic features which are potentially influenced by inflammation, mutagens, and/or microbiota. CRCs...