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mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants

posted 2 days

Mashup Score: 32

bioRxiv - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative infection of a global pandemic that has led to more than 2 million deaths worldwide....

bioRxiv - Changes in a few key transcriptional regulators can lead to different biological states, including cell activation and differentiation, and diseases. Extracting the key gene...

  • RegEnrich: An R package for gene regulator enrichment analysis reveals key role of ETS transcription factor family in interferon signaling https://t.co/qQRnjLT7aB #bioRxiv

Variant and mutation analysis of SARS-CoV-2 genomes isolated from the Kingdom of Bahrain

posted 12 hours

Mashup Score: 3

bioRxiv - The challenges imposed by the ongoing outbreak of severe acute respiratory syndrome coronavirus-2 affects every aspect of our modern world, ranging from our health...

A novel SARS-CoV-2 related coronavirus in bats from Cambodia

posted 12 hours

Mashup Score: 3

bioRxiv - Knowledge of the origin and reservoir of the coronavirus responsible for the ongoing COVID-19 pandemic is still fragmentary. To date, the closest relatives to...

bioRxiv - We propose TWO-SIGMA-G, a competitive gene set test designed for scRNA-seq data. TWO-SIGMA-G uses the mixed-effects regression modelling approach of our previously published TWO-SIGMA...

  • TWO-SIGMA-G: A New Competitive Gene Set Testing Framework for scRNA-seq Data Accounting for Inter-Gene and Cell-Cell Correlation https://t.co/GtRF7ie5Ns #bioRxiv

martini: an R package for genome-wide association studies using SNP networks

posted 16 hours

Mashup Score: 2

bioRxiv - Systems biology shows that genes that are related to the same phenotype are often functionally related. We can take advantage of this to discover...

Identification of LINE retrotransposons and long non-coding RNAs expressed in the octopus brain

posted 2 days

Mashup Score: 2

bioRxiv - Transposable elements (TEs) widely contributed to the evolution of genomes allowing genomic innovations, generating germinal and somatic heterogeneity and giving birth to long non-coding...

Lost in translation: codon optimization inactivates SARS-CoV-2 RdRp

posted 1 day

Mashup Score: 2

bioRxiv - RNA-dependent RNA polymerase (RdRp) is a primary target for antivirals. We report that Nsp12, a catalytic subunit of SARS-CoV-2 RdRp, produces an inactive enzyme...

bioRxiv - Type I interferons (IFN α/β) play a central role in innate immunity to respiratory viruses, including coronaviruses. Genetic defects in type I interferon signaling...

  • Profiling transcription factor sub-networks in type I interferon signaling and in response to SARS-CoV-2 infection https://t.co/i1wzgSn2RC #bioRxiv

A joint analysis of longevity and age-related disease variants for gene expression association

posted 7 hours

Mashup Score: 2

bioRxiv - A large number of genetic variants associated with human longevity have been reported but how they play their functions remains elusive. We performed an...