Twitter Feed: bioRxiv
Rapid and accurate deorphanization of ligand-receptor pairs using AlphaFold - 1 week
Secreted proteins are extracellular ligands that play key roles in paracrine and endocrine signaling, classically by binding cell surface receptors. Experimental assays to identify...
Rapid and accurate deorphanization of ligand-receptor pairs using AlphaFold https://t.co/n8es5WDpF2 #bioRxiv - view on twitter
Mechanisms of transcription control by distal enhancers from high-resolution single-gene imaging - 6 days
How distal enhancers physically control promoters over large genomic distances, to enable cell-type specific gene expression, remains obscure. Using single-gene super-resolution imaging and acute...
Mechanisms of transcription control by distal enhancers from high-resolution single-gene imaging https://t.co/77fkQsSucZ #bioRxiv - view on twitter
How total mRNA influences cell growth - 5 days
While the conventional wisdom is that growth rate is prominently set by ribosome amounts, in many biologically relevant situations the levels of mRNA and...
How total mRNA influences cell growth https://t.co/tXOAJfZbT8 #bioRxiv - view on twitter
Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo - 6 days
Guide RNAs offer programmability for CRISPR-Cas9 genome editing but also add challenges for delivery. Chemical modification, which has been key to the success of...
Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo https://t.co/mBEUJChgYc #bioRxiv - view on twitter
Diverse and Abundant Viruses Exploit Conjugative Plasmids - 7 days
Viruses exert profound evolutionary pressure on bacteria by interacting with receptors on the cell surface to initiate infection. While the majority of bacterial viruses,...
Diverse and Abundant Viruses Exploit Conjugative Plasmids https://t.co/GT1WUnlhOd #bioRxiv - view on twitter
Identification of mammalian transcription factors that bind to inaccessible chromatin - 1 week
Transcription factors (TFs) are proteins that affect gene expression by binding to regulatory regions of DNA in a sequence specific manner. The binding of...
Identification of mammalian transcription factors that bind to inaccessible chromatin https://t.co/DguF9IfAaD #bioRxiv - view on twitter
Intake of Western diet stimulates bile acid (BA) production and their conversion to secondary BAs by 7α-dehydroxylating (7αDH+) bacteria in the colon. Increased levels...
Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer https://t.co/dx7X2lYDpy #bioRxiv - view on twitter
Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor - 22 hours
Human immunodeficiency virus (HIV) and other lentiviruses adapt to new hosts by evolving to evade host-specific innate immune proteins that differ in sequence and...
Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor https://t.co/7X5x8Pq3To #bioRxiv - view on twitter
Faithful DNA replication requires that cells fine-tune their histone pool in coordination with cell-cycle progression. Replication-dependent histone biosynthesis is initiated at a low level...
Cyclin E/CDK2 and feedback from soluble histone protein regulate the S phase burst of histone biosynthesis https://t.co/GAFUoSkRTQ #bioRxiv - view on twitter
Traditional genome-editing reagents such as CRISPR-Cas9 achieve targeted DNA modification by introducing double-strand breaks (DSBs), thereby stimulating localized DNA repair by endogenous cellular repair...
Targeted DNA integration in human cells without double-strand breaks using CRISPR RNA-guided transposases https://t.co/lj5aPihHw0 #bioRxiv - view on twitter