Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus

The field of neutrophil biology has lagged behind in terms of the understanding of heterogeneity and versatility of cellular functions, limiting the development of therapeutic approaches that target aberrant neutrophil phenotypes. Using bulk and single-cell transcriptomic, epigenetic, and functional analyses, this study highlights aspects of neutrophil heterogeneity and their putative role in the…

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